Structural biology of proteins that may the be targets of insect control strategies

• Processo: 01/07531-4
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Data de Início da vigência: 01 de outubro de 2001
• Data de Término da vigência: 31 de dezembro de 2005
• Área do conhecimento: Ciências Biológicas - Bioquímica
• Pesquisador responsável: Walter Ribeiro Terra
• Beneficiário: Walter Ribeiro Terra
• Instituição Sede: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brasil
• Assunto(s): beta-Glucosidase Muramidase Peritrofinas Tripsinas
• Palavra(s)-Chave do Pesquisador: Beta-Glycosidases | Lysozymes | Peritrophins | Trypsins

Resumo

Four types of insect proteins have been selected and the resolution of their structures are expected to be reavealing. The proteins are: beta-glycosidases, digestive lysozymes, trypsins and peritrophins. These proteins are being studied in our laboratory and we have cloned and expressed one of the beta-glycosidases, we have clones of lysozymes and some trypsins and one peritrophin have been purified to homogeneity. We are also interested in helping to study proteins coded by genomes of Brazilian interest. We are particularly interested in glycoside hydrolases and peptide hydrolases and their protein inhibitors. (AU)

Publicações científicas

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

CANCADO, F. C.; EFFIO, P. CHIMOY; TERRA, W. R.; MARANA, S. R.. Cloning, purification and comparative characterization of two digestive lysozymes from Musca domestica larvae. Brazilian Journal of Medical and Biological Research, v. 41, n. 11, p. 969-977, NOV 2008. (04/02225-0, 01/07531-4, 06/56521-5)