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Ano de início
Entree

The genetic architecture and evolution of pleiotropy associated with evolutionary changes in developmental trajetories

Processo: 13/50402-8
Linha de fomento:Auxílio à Pesquisa - Regular
Vigência: 01 de fevereiro de 2015 - 31 de janeiro de 2019
Área do conhecimento:Ciências Biológicas - Genética - Genética Quantitativa
Convênio/Acordo: BBSRC, UKRI
Pesquisador responsável:Gabriel Henrique Marroig Zambonato
Beneficiário:Gabriel Henrique Marroig Zambonato
Pesq. responsável no exterior: Jason Barry Wolf
Instituição no exterior: University of Bath, Inglaterra
Instituição-sede: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brasil
Assunto(s):Pleiotropia genética  Linhagem  Análise multivariada  Evolução molecular  Variação genética 
Publicação FAPESP:https://media.fapesp.br/bv/uploads/pdfs/fapesp_uk_Lhv9bzb_34_34.pdf

Resumo

Individuals are composed of suites of traits that arise from a common genome through shared developmental processes that together determine their fitness. Consequently, fundamental to our understanding of the genetic basis and evolution of complex traits is the concept of pleiotropy, where a single gene affects the expression of multiple traits. Although patterns of pleiotropy have important genetic and evolutionary implications, we have a limited understanding of their genomic basis and evolution. We propose to advance our understanding of pleiotropy using an experimental system in which multivariate selection has been used to reshape patterns of growth and development in mice. By focusing on developmental traits we will also further our understanding of the relationship between the traits produced by the developmental system. To achieve our goals we will apply cutting edge computational tools in an experimental population created by intercrossing mouse strains with highly divergent ontogenies. Using these tools we will map molecular variation to multidimensional phenotypic variation to achieve the following objectives. 1) Characterize the patterns of pleiotropic effects that contributed to multivariate evolution 2) Examine whether pleiotropic effects constrained the patterns of genetic variation 3) Determine the role that context-dependent pleiotropic effects played in shaping patterns of multivariate evolution 4) Determine the contribution of maternal effects to patterns of pleiotropy 5) Understand how ontogenetic changes impact patterns of pleiotropy among adult traits, 6) Determine the contribution of genomic imprinting to patterns of pleiotropy. (AU)

Publicações científicas
(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)
MELO, DIOGO; MARROIG, GABRIEL; WOLF, JASON B. Genomic Perspective on Multivariate Variation, Pleiotropy, and Evolution. JOURNAL OF HEREDITY, v. 110, n. 4, SI, p. 479-493, JUN 2019. Citações Web of Science: 0.

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