Baroreceptor reflex sensitivity under postural, respiratory and mental stress

• Processo: 99/03616-3
• Modalidade de apoio: Bolsas no Exterior - Pesquisa
• Data de Início da vigência: 26 de agosto de 1999
• Data de Término da vigência: 25 de agosto de 2001
• Área de conhecimento: Ciências Biológicas - Fisiologia - Fisiologia do Esforço
• Pesquisador responsável: Roseli Golfetti
• Beneficiário: Roseli Golfetti
• Pesquisador Anfitrião: Benjamin H. Natelson
• Instituição Sede: Faculdade de Educação Física (FEF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brasil
• Instituição Anfitriã: University of Medicine and Dentistry of New Jersey, Estados Unidos
• Assunto(s): Síndrome de fadiga crônica Intolerância ortostática Estresse
• Palavra(s)-Chave do Pesquisador: Chronic Fatigue Syndrome | Lower Body Negative Pressure | Orthostatic Tolarence | Peripherical Resistance | Stroke Volume

Resumo

Chronic Fatigue Syndrome (CFS) is a condition that results in moderate to severe disability, the primary feature of which is fatigue of unknown origin. The major symptom is debilitating fatigue of more than 6 months' duration associated with a marked decrease in daily activity that cannot be attributed to any known medical cause. Some CFS's patients present cardiovascular disturbs, one of them is the lower stroke volume, that might be due to peripheral vascular abnormalities. To determine this hypothesis, it will be done by producing graded increases in lower body negative pressure (LBNP) to induce progressive venous pooling in a controlled manner to simulate the cardiovascular effects of gravity. This study will also determine whether the CFS patients complaint of increased symptoms when they stand up quickly might be due to inadequate cardiovascular responses to postural change. (AU)