The effects of total sleep deprivation on sleep rebound after treatment with gabaa-benzodiazepine receptor agonists, zolpidem and diazepam in healthy subjects

• Processo: 99/01954-9
• Modalidade de apoio: Bolsas no Exterior - Pesquisa
• Data de Início da vigência: 25 de agosto de 1999
• Data de Término da vigência: 03 de fevereiro de 2001
• Área de conhecimento: Ciências Biológicas - Farmacologia - Neuropsicofarmacologia
• Pesquisador responsável: Dalva Lucia Rollemberg Poyares
• Beneficiário: Dalva Lucia Rollemberg Poyares
• Pesquisador Anfitrião: Christian Guilleminault
• Instituição Sede: Associação Fundo de Incentivo a Psicofarmacologia (AFIP). Departamento de Psicobiologia. Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brasil
• Instituição Anfitriã: Stanford University, Estados Unidos
• Assunto(s): Diazepam
• Palavra(s)-Chave do Pesquisador: Diazepam | Sleep Deprivation | Sleep Eeg | Sleep Rebound | Zolpidem

Resumo

It's known that sleep deprivation (SD) can rapidly change the GABAa receptor. Sleep rebound is a homeosthatic response wich follows the SD. Zolpidem is a very selective GABAa-benzodiazepine agonist to the hypnotic effect, while Diazepam does not present such a selectivity. The main goal of this study is to investigate how sleep rebound and the hypnotic effect of those agonists could be affected by SD using the Sleep EEG frequency analysis technique. (AU)