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Entree

IMMUNOGENIC COMPLEX FORMED BY VACCINAL ANTIGENS ENCAPSULATED BY NANOSTRUCTURED MESOPOROUS SILICA

EscritórioCIPO
Tipo de documento:Patente
Inventor(es): Ogari De Castro Pacheco; Osvaldo Augusto Brazil Esteves Sant'Anna; Lucildes Pita Mercuri; Jivaldo Do Rosário Matos; Marcia Carvalho De Abreu Fantini
Depositante:Cristália Produtos Químicos Farmacêuticos Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Ano: 2006
Número do Pedido:CA 2621373
IPC: A61K 39/00 A61K 39/39
Resumo

The present invention relates to a product named "immunogenic complex", which comprises an adjuvant characterized by solid particles of highly nanostructured mesoporous silica, preferably, the silica SBA-15, and vaccinal antigens of distinct nature, encapsulated in this kind of adjuvant. The immunogenic complex of the present invention allows the presentation of the antigens to lymphocytes, in a safe, gradual and sustained way, which leads to a more efficient immunological memory, increases in the immunogenicity of the antigen and improves the production of antibodies. It ensures efficient immunological protection with lower amounts of antigens and/or less repetition of vaccinal doses. In addition, the characteristics of the immunogenic complex of the present invention promote effective immunity induction, homogeneous in "high and low responder" individuals.


Processo FAPESP: 04/11597-9 - Estudo experimental do efeito adjuvante da silica nanoestruturada sba-15.
Beneficiário:Luciana Vieira Carvalho
Pesquisador responsável:Osvaldo Augusto Brazil Esteves Sant'Anna
Instituição: Secretaria da Saúde (São Paulo - Estado). Instituto Butantan
Modalidade de apoio: Bolsas no Brasil - Mestrado