Spectroscopic, luminescence and in vitro biological studies of solid ketoprofen of heavier trivalent lanthanides and yttrium(III)

Autor(es)

Galico, D. A. ^[1] ; Lahoud, M. G. ^[2] ; Davolos, M. R. ^[2] ; Frem, R. C. G. ^[2] ; Fraga-Silva, T. F. C. ^[3] ; Venturini, J. ^[4] ; Arruda, M. S. P. ^[4] ; Bannach, G. ^[1]

Afiliação do(s) autor(es)

^[1] UNESP, Fac Ciencias, Dept Quim, BR-17033260 Bauru, SP - Brazil

^[2] UNESP, Inst Quim, Dept Quim Inorgan, BR-14801970 Araraquara, SP - Brazil

^[3] UNESP, Inst Biociencias, Dept Microbiol & Imunol, BR-18618970 Botucatu, SP - Brazil

^[4] UNESP, Fac Ciencias, Dept Ciencias Biol, BR-17033260 Bauru, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Inorganic Biochemistry; v. 140, p. 160-166, NOV 2014.
• Citações Web of Science: 18

Resumo

Solid-state compounds of the general formulae {[}ML3] (M = Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Y; L = ketoprofen) were synthesized and characterized using infrared, diffuse reflectance and luminescence spectroscopies. IR data suggested that the carboxylate group in ketoprofen is coordinated to the metals as a bidentate ligand. The triplet state energy level was determined using the Gd3+ complex, which exhibited a ketoprofen blue luminescence when excited in the UV region. The compound containing Tb3+ ion was sensitized by the ligand and emitted in the green region of the visible spectrum. On the other hand, for the analogous species containing the dysprosium ion, a competition for luminescence between the Dy3+ and the ligand levels was observed. Finally, Tm3+ complex exhibits only ligand luminescence. These optical behaviors are discussed based on rare earth energy diagrams. In addition, the compounds were evaluated for their anti-inflammatory activities. All the compounds showed a higher production of H2O2 and IL-10 than the ketoprofen, suggesting that the compounds exhibited an immunomodulatory effect and this opens up new perspectives for immunotherapeutic approaches. (C) 2014 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 12/21450-1 - Estudos termoanalíticos, síntese e caracterização dos co-cristais sólidos de cetoprofeno com alguns co-formadores
• Beneficiário: Gilbert Bannach
• Modalidade de apoio: Auxílio à Pesquisa - Regular