| Full text | |
| Author(s): |
Galico, D. A.
[1]
;
Lahoud, M. G.
[2]
;
Davolos, M. R.
[2]
;
Frem, R. C. G.
[2]
;
Fraga-Silva, T. F. C.
[3]
;
Venturini, J.
[4]
;
Arruda, M. S. P.
[4]
;
Bannach, G.
[1]
Total Authors: 8
|
| Affiliation: | [1] UNESP, Fac Ciencias, Dept Quim, BR-17033260 Bauru, SP - Brazil
[2] UNESP, Inst Quim, Dept Quim Inorgan, BR-14801970 Araraquara, SP - Brazil
[3] UNESP, Inst Biociencias, Dept Microbiol & Imunol, BR-18618970 Botucatu, SP - Brazil
[4] UNESP, Fac Ciencias, Dept Ciencias Biol, BR-17033260 Bauru, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Journal of Inorganic Biochemistry; v. 140, p. 160-166, NOV 2014. |
| Web of Science Citations: | 18 |
| Abstract | |
Solid-state compounds of the general formulae {[}ML3] (M = Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Y; L = ketoprofen) were synthesized and characterized using infrared, diffuse reflectance and luminescence spectroscopies. IR data suggested that the carboxylate group in ketoprofen is coordinated to the metals as a bidentate ligand. The triplet state energy level was determined using the Gd3+ complex, which exhibited a ketoprofen blue luminescence when excited in the UV region. The compound containing Tb3+ ion was sensitized by the ligand and emitted in the green region of the visible spectrum. On the other hand, for the analogous species containing the dysprosium ion, a competition for luminescence between the Dy3+ and the ligand levels was observed. Finally, Tm3+ complex exhibits only ligand luminescence. These optical behaviors are discussed based on rare earth energy diagrams. In addition, the compounds were evaluated for their anti-inflammatory activities. All the compounds showed a higher production of H2O2 and IL-10 than the ketoprofen, suggesting that the compounds exhibited an immunomodulatory effect and this opens up new perspectives for immunotherapeutic approaches. (C) 2014 Elsevier Inc. All rights reserved. (AU) | |
| FAPESP's process: | 12/21450-1 - Thermoanalytical studies, synthesis and characterization of the solid co-crystals of ketoprofen with some co-formers |
| Grantee: | Gilbert Bannach |
| Support Opportunities: | Regular Research Grants |