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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Spectroscopic, luminescence and in vitro biological studies of solid ketoprofen of heavier trivalent lanthanides and yttrium(III)

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Galico, D. A. [1] ; Lahoud, M. G. [2] ; Davolos, M. R. [2] ; Frem, R. C. G. [2] ; Fraga-Silva, T. F. C. [3] ; Venturini, J. [4] ; Arruda, M. S. P. [4] ; Bannach, G. [1]
Total Authors: 8
[1] UNESP, Fac Ciencias, Dept Quim, BR-17033260 Bauru, SP - Brazil
[2] UNESP, Inst Quim, Dept Quim Inorgan, BR-14801970 Araraquara, SP - Brazil
[3] UNESP, Inst Biociencias, Dept Microbiol & Imunol, BR-18618970 Botucatu, SP - Brazil
[4] UNESP, Fac Ciencias, Dept Ciencias Biol, BR-17033260 Bauru, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Inorganic Biochemistry; v. 140, p. 160-166, NOV 2014.
Web of Science Citations: 18

Solid-state compounds of the general formulae {[}ML3] (M = Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Y; L = ketoprofen) were synthesized and characterized using infrared, diffuse reflectance and luminescence spectroscopies. IR data suggested that the carboxylate group in ketoprofen is coordinated to the metals as a bidentate ligand. The triplet state energy level was determined using the Gd3+ complex, which exhibited a ketoprofen blue luminescence when excited in the UV region. The compound containing Tb3+ ion was sensitized by the ligand and emitted in the green region of the visible spectrum. On the other hand, for the analogous species containing the dysprosium ion, a competition for luminescence between the Dy3+ and the ligand levels was observed. Finally, Tm3+ complex exhibits only ligand luminescence. These optical behaviors are discussed based on rare earth energy diagrams. In addition, the compounds were evaluated for their anti-inflammatory activities. All the compounds showed a higher production of H2O2 and IL-10 than the ketoprofen, suggesting that the compounds exhibited an immunomodulatory effect and this opens up new perspectives for immunotherapeutic approaches. (C) 2014 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 12/21450-1 - Thermoanalytical studies, synthesis and characterization of the solid co-crystals of ketoprofen with some co-formers
Grantee:Gilbert Bannach
Support type: Regular Research Grants