Determination of alpha-Lipoic acid on a Pyrolytic Graphite Electrode Modified with Cobalt Phthalocyanine

Autor(es)

Ferreira, Ana Paula M. ^[1] ; dos Santos Pereira, Laise N. ^[1] ; da Silva, Iranaldo Santos ^{[1, 2]} ; Tanaka, Sonia M. C. N. ^[1] ; Tanaka, Auro A. ^{[1, 3]} ; Angnes, Lucio ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Maranhao, Dept Quim, BR-65080805 Sao Luis, MA - Brazil

^[2] Univ Sao Paulo, Inst Quim, BR-05508000 Sao Paulo, SP - Brazil

^[3] Inst Nacl Ciencia Tecnol Bioanalit, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Electroanalysis; v. 26, n. 10, p. 2138-2144, OCT 2014.
• Citações Web of Science: 6

Resumo

In this work voltammetric techniques were explored for quantification of a-Lipoic acid (ALA) using a pyrolytic graphite electrode modified with cobalt phthalocyanine. Cyclic voltammograms recorded in phosphate buffer solution containing 1 x 10(-3) mol L-1 of ALA presented an oxidation peak located at +0.8 V vs. SCE. The modification of the electrode produced a 100 mV shift of the onset oxidation potential to less positive value and a substantial increase in the ALA oxidation current. Among the voltammetric techniques explored, differential pulse voltammetry showed the best performance for quantifications of the analyte in low concentrations. Limits of detection and quantification of ALA obtained corresponds to 3.4 x 10(-9) mol L-1 and 1.2 x 10(-8) mol L-1, respectively. (AU)

• Processo FAPESP: 13/16960-3 - Desenvolvimento de sensores voltamétricos contendo sílica mesoporosa modificados com nanopartículas de Au e compostos nitro heterocíclicos com atividade antichagásica - Aplicações Bioeletroquímicas
• Beneficiário: Iranaldo Santos da Silva
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado