Novel Formulations for Antimicrobial Peptides

Autor(es)

Carmona-Ribeiro, Ana Maria ^[1] ; de Melo Carrasco, Leticia Dias ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim, Biocolloids Lab, BR-05508000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 15, n. 10, p. 18040-18083, OCT 2014.
• Citações Web of Science: 56

Resumo

Peptides in general hold much promise as a major ingredient in novel supramolecular assemblies. They may become essential in vaccine design, antimicrobial chemotherapy, cancer immunotherapy, food preservation, organs transplants, design of novel materials for dentistry, formulations against diabetes and other important strategical applications. This review discusses how novel formulations may improve the therapeutic index of antimicrobial peptides by protecting their activity and improving their bioavailability. The diversity of novel formulations using lipids, liposomes, nanoparticles, polymers, micelles, etc., within the limits of nanotechnology may also provide novel applications going beyond antimicrobial chemotherapy. (AU)

• Processo FAPESP: 12/24534-1 - Arranjos supramoleculares de lípide catiônico, antibióticos e polímeros: preparação, caracterização e atividade contra bactérias multirresistentes e micobactérias de crescimento rápido
• Beneficiário: Letícia Dias de Melo Carrasco
• Modalidade de apoio: Bolsas no Brasil - Doutorado