Novel Formulations for Antimicrobial Peptides

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Author(s):	Carmona-Ribeiro, Ana Maria ^[1] ; de Melo Carrasco, Leticia Dias ^[1] Total Authors: 2
Affiliation:	^[1] Univ Sao Paulo, Inst Quim, Biocolloids Lab, BR-05508000 Sao Paulo, SP - Brazil Total Affiliations: 1
Document type:	Review article
Source:	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 15, n. 10, p. 18040-18083, OCT 2014.
Web of Science Citations:	56
Abstract
Peptides in general hold much promise as a major ingredient in novel supramolecular assemblies. They may become essential in vaccine design, antimicrobial chemotherapy, cancer immunotherapy, food preservation, organs transplants, design of novel materials for dentistry, formulations against diabetes and other important strategical applications. This review discusses how novel formulations may improve the therapeutic index of antimicrobial peptides by protecting their activity and improving their bioavailability. The diversity of novel formulations using lipids, liposomes, nanoparticles, polymers, micelles, etc., within the limits of nanotechnology may also provide novel applications going beyond antimicrobial chemotherapy. (AU)

FAPESP's process:	12/24534-1 - Supramolecular assemblies of cationic lipid, antibiotics and polymers: preparation, characterization and activity against multiresistant bacteria and fast-growing mycobacteria
Grantee:	Letícia Dias de Melo Carrasco
Support Opportunities:	Scholarships in Brazil - Doctorate