| Grant number: | 12/24534-1 |
| Support type: | Scholarships in Brazil - Doctorate |
| Effective date (Start): | March 01, 2013 |
| Effective date (End): | June 30, 2016 |
| Field of knowledge: | Biological Sciences - Biophysics - Molecular Biophysics |
| Principal Investigator: | Ana Maria Carmona-Ribeiro |
| Grantee: | Letícia Dias de Melo Carrasco |
| Home Institution: | Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Abstract The cationic lipid dioctadecyldimethylammonium bromide (DODAB) self-assembles as bilayer fragments (BF) or large bilayer vesicles (LV) in water depending on the dispersion method and are established as potent antimicrobial agents. On the other hand, vesicles and liposomes can be used as carriers for antibiotics able to deliver drugs inside cells such as the macrophages. Novel hybrid microbicidal materials are being developed by our group based on cationic lipid and polymers to address the problem of multiresistant bacteria and /or fast-growing mycobacteria. The novel supramolecular assemblies will be characterized by dynamic light scattering, determination of antibiotic incorporation from dialysis experiments, determination of bacteria viability by plating and CFU (colony forming unities) counting and determination of macrophages viability in the presence of bacteria and the novel formulations. (AU) | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
| Researchers test nanoparticles against multidrug-resistant bacteria | |
| Researchers test nanoparticles against multidrug-resistant bacteria | |