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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antimicrobial Particles from Emulsion Polymerization of Methyl Methacrylate in the Presence of Quaternary Ammonium Surfactants

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Author(s):
Naves, Alliny F. [1] ; Palombo, Renata R. [1] ; Carrasco, Leticia D. M. [1] ; Carmona-Ribeiro, Ana M. [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, Biocolloids Lab, BR-05513970 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Langmuir; v. 29, n. 31, p. 9677-9684, AUG 6 2013.
Web of Science Citations: 21
Abstract

The purpose of this Article is to characterize polymeric particles of poly(methylmethacrylate) (PMMA) synthesized in the presence of one of two different quaternary ammonium surfactants (QACs): cetyltrimethylammonium bromide (CTAB) or dioctadecyldimethylammonium bromide (DODAB). The methods used are dynamic light scattering for sizing, polydispersity and zeta potential analysis, scanning electron microscopy (SEM) for morphology visualization, and plating plus colony-forming unities (CFU) counting for the determination of antimicrobial activity. The results point out the high QAC concentration required to obtain cationic and bioactive antimicrobial particles with good colloidal stability and a permanent load of the polymeric network with QACs. Over a range of micromolar QAC concentrations, there is remarkable antimicrobial activity of PMMA/CTAB or PMMA/DODAB particles, which is much higher than those determined for the QACs by themselves. Loading the biocompatible polyacrylate particles with QACs is a facile, fast, low-cost approach to obtaining highly efficient antimicrobial nanoparticles. (AU)

FAPESP's process: 12/24534-1 - Supramolecular assemblies of cationic lipid, antibiotics and polymers: preparation, characterization and activity against multiresistant bacteria and fast-growing mycobacteria
Grantee:Letícia Dias de Melo Carrasco
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 11/00046-5 - Interactions between membranes, biomolecules and surfaces
Grantee:Ana Maria Carmona-Ribeiro
Support Opportunities: Regular Research Grants