Supramolecular assemblies with immunoadjuvant or antimicrobial activity

• Grant number: 19/17685-2
• Support type: Regular Research Grants
• Duration: May 01, 2020 - April 30, 2022
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Ana Maria Carmona-Ribeiro
• Grantee: Ana Maria Carmona-Ribeiro
• Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Assoc. researchers: Eliana Faquim de Lima Mauro
• Associated scholarship(s): 20/08078-2 - Preparation, characterization and antimicrobial activity of nanoparticles and silica films covered by a cationic lipid bilayer incorporating gramicidin and its respective films obtained by deposition, BP.TT

Abstract

Our laboratory is dedicated to the development of novel supramolecular assemblies for presenting antigens or for improving the antimicrobial action against resistant microbes. The constructions will rely on intermolecular interactions between polymers, lipids, biomolecules, surfactants, antigens and other significant molecules to build effective immunoadjuvants or microbicides.Preparation, characterization and bioactivity will be determined by classical but sometimes sophisticated techniques like dynamic light-scattering, morphology of nanoparticles, films and cells from scanning electron microscopy, determination of cells viability for microrganisms and model mammalian cells like cultured fibroblasts. Not only the effectiveness of the assemblies will be evaluated but also their toxicity. (AU)