Leishmanicidal galloylquinic acids are noncompetitive inhibitors of arginase

Autor(es)

de Sousa, Lorena R. F. ^[1] ; Ramalho, Suelem D. ^[1] ; Fernandes, Joao B. ^[1] ; da Silva, Maria Fatima das G. F. ^[1] ; Iemma, Monica R. da C. ^[1] ; Correa, Caroindes J. ^[1] ; de Souza, Dulce H. F. ^[1] ; Lima, Maria I. S. ^[2] ; Vieira, Paulo C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Bot, BR-13565905 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 25, n. 10, p. 1832+, OCT 2014.
• Citações Web of Science: 5

Resumo

Leishmanicidal galloylquinic acids were isolated from the ethyl acetate extract of Byrsonima coccolobifolia. These phenols and gallic acid showed to be a new class of potent noncompetitive inhibitors of arginase ARG (Ki ranging from 0.10 to 0.68 µmol L-1) from Leishmania amazonensis. Quinic acid did not exhibit significant inhibition of ARG, indicating that galloyl moiety has important features that allows the enzyme-inhibitor interactions. The significant inhibitory activity of gallic acid on ARG can be a clue to understand the immune response previously observed on L. donovani, since ARG activity is associated with the decrease of the levels of NO in Leishmania infection. (AU)

• Processo FAPESP: 10/52326-9 - Estudo de produtos naturais oriundos de plantas do cerrado e mata atlântica: conhecimento químico-biológico aliado à preservação
• Beneficiário: Paulo Cézar Vieira
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Regular