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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Leishmanicidal galloylquinic acids are noncompetitive inhibitors of arginase

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Author(s):
de Sousa, Lorena R. F. [1] ; Ramalho, Suelem D. [1] ; Fernandes, Joao B. [1] ; da Silva, Maria Fatima das G. F. [1] ; Iemma, Monica R. da C. [1] ; Correa, Caroindes J. [1] ; de Souza, Dulce H. F. [1] ; Lima, Maria I. S. [2] ; Vieira, Paulo C. [1]
Total Authors: 9
Affiliation:
[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Bot, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 25, n. 10, p. 1832+, OCT 2014.
Web of Science Citations: 5
Abstract

Leishmanicidal galloylquinic acids were isolated from the ethyl acetate extract of Byrsonima coccolobifolia. These phenols and gallic acid showed to be a new class of potent noncompetitive inhibitors of arginase ARG (Ki ranging from 0.10 to 0.68 µmol L-1) from Leishmania amazonensis. Quinic acid did not exhibit significant inhibition of ARG, indicating that galloyl moiety has important features that allows the enzyme-inhibitor interactions. The significant inhibitory activity of gallic acid on ARG can be a clue to understand the immune response previously observed on L. donovani, since ARG activity is associated with the decrease of the levels of NO in Leishmania infection. (AU)