Temperature-Driven Isosymmetric Reversible Phase Transition of the Hormone Estradiol 17 beta Valerate

Autor(es)

Ellena, Javier ^[1] ; de Paula, Karina ^[1] ; de Melo, Cristiane C. ^[1] ; da Silva, Cecilia C. P. ^[1] ; Bezerra, Beatriz P. ^[2] ; Venancio, Tiago ^[3] ; Ayala, Alejandro P. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Paulo - Brazil

^[2] Univ Fed Ceara, Dept Fis, Fortaleza, Ceara - Brazil

^[3] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Crystal Growth & Design; v. 14, n. 11, p. 5700-5709, NOV 2014.
• Citações Web of Science: 8

Resumo

The hormone estradiol 17 beta valerate (E2V), used in hormone replacement therapy, undergoes a structural phase transition at 251.1 K on cooling. The crystalline structure of the low and room temperature phases were determined showing that neither the space group nor the site symmetry and number of atoms are altered. These phases are related by a large conformational reorientation of the valerate chain. In addition, thermal analysis, solid state nuclear magnetic resonance, and infrared spectroscopy show that the transformation is reversible, discontinuous, and first order, evidencing the occurence of an isosymmetric phase transition, rare for organic compounds. (AU)

• Processo FAPESP: 09/54035-4 - EMU: facility para estudos avançados de materiais nanoestruturados e biossistemas / FAMA
• Beneficiário: Igor Polikarpov
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários