| Full text | |
| Author(s): |
Ellena, Javier
[1]
;
de Paula, Karina
[1]
;
de Melo, Cristiane C.
[1]
;
da Silva, Cecilia C. P.
[1]
;
Bezerra, Beatriz P.
[2]
;
Venancio, Tiago
[3]
;
Ayala, Alejandro P.
[2]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Paulo - Brazil
[2] Univ Fed Ceara, Dept Fis, Fortaleza, Ceara - Brazil
[3] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Crystal Growth & Design; v. 14, n. 11, p. 5700-5709, NOV 2014. |
| Web of Science Citations: | 8 |
| Abstract | |
The hormone estradiol 17 beta valerate (E2V), used in hormone replacement therapy, undergoes a structural phase transition at 251.1 K on cooling. The crystalline structure of the low and room temperature phases were determined showing that neither the space group nor the site symmetry and number of atoms are altered. These phases are related by a large conformational reorientation of the valerate chain. In addition, thermal analysis, solid state nuclear magnetic resonance, and infrared spectroscopy show that the transformation is reversible, discontinuous, and first order, evidencing the occurence of an isosymmetric phase transition, rare for organic compounds. (AU) | |
| FAPESP's process: | 09/54035-4 - Facility for advanced studies of biosystems and nanostructured materials |
| Grantee: | Igor Polikarpov |
| Support Opportunities: | Multi-user Equipment Program |