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Facility for advanced studies of biosystems and nanostructured materials

Grant number: 09/54035-4
Support type:Multi-user Equipment Program
Duration: August 01, 2010 - July 31, 2013
Field of knowledge:Biological Sciences - Biophysics - Molecular Biophysics
Principal Investigator:Igor Polikarpov
Grantee:Igor Polikarpov
Home Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
As informações de acesso ao Equipamento Multiusuário são de responsabilidade do Pesquisador responsável
EMU web page: Página do Equipamento Multiusuário não informada
Tipo de equipamento: Tipo de Equipamento Multiusuário não informado
Fabricante: Fabricante não informado
Modelo: Modelo não informado

Abstract

This proposal is aimed at modernizing and expanding a multi-user centralized laboratory (facility) that has been in operation for more than 20 years at the USP São Carlos Institute of Physics (IFSC), doing research and providing services in the area of inorganic and organic materials with techniques of scanning electron microscopy, atomic force microscopy and X-ray diffraction, meeting the needs of researchers in the state of São Paulo and in other Brazilian states. The modernization and the expansion will bring together modern techniques of confocal microscopy and dual-wavelength X-ray diffraction, as well as highresolution electron microscopy, field-emission gun scanning electron microscopy, and state-of-the-art atomic force microscopy. With this expansion of the laboratory, it will be possible to broaden the gamut of materials investigated and to serve a greater number of researchers, with personnel highly qualified. In addition, the growing multidisciplinary emphasis at the IFSC has brought new demands for methodologies that make it possible to investigate organic and inorganic nanostructures, soft matter, biomass, and biosystems in general (confocal microscopy). The project is supported by two FAPESP Centers for Research, Innovation and Dissemination grants, three National Institute of Science and Technology grants, three FAPESP Thematic Project grants, one FAPESP Regular Project grant, and one Financing Agency for Studies and Projects grant, together with other associated project grants, totaling over 75 million Brazilian reals in financial resources, as well as various complementary grants. Through these projects, we seek to understand physical, physicochemical, and biological processes on the atomic and nanometric scales, in cutting-edge areas to which the groups participating in this proposal have made significant contributions at the international level. Because of the broad (statewide and nationwide) scope of some of the associated projects, considerable number of researchers and specialists in technological innovation in the state of São Paulo will benefit, principally in terms of the infrastructure and the training of technicians at the IFSC to facilitate the sharing of the multi-user equipment. (AU)

Scientific publications (29)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FRANCISCONI, RENATA SERIGNOLI; MAQUERA-HUACHO, PATRICIA MILAGROS; TONON, CAROLINE CORADI; FIORAMONTI CALIXTO, GIOVANA MARIA; ORLANDI SARDI, JANAINA DE CASSIA; CHORILLI, MARLUS; PALOMARI SPOLIDORIO, DENISE MADALENA. Terpinen-4-ol and nystatin co-loaded precursor of liquid crystalline system for topical treatment of oral candidiasis. SCIENTIFIC REPORTS, v. 10, n. 1 JUL 31 2020. Web of Science Citations: 0.
MACHADO, THIAGO S.; MACABELLI, CAROLINA H.; DEL COLLADO, MAITE; MEIRELLES, V, FLAVIO; GUIMARAES, FRANCISCO E. G.; CHIARATTI, MARCOS R. Evidence of Selection Against Damaged Mitochondria During Early Embryogenesis in the Mouse. FRONTIERS IN GENETICS, v. 11, JUL 15 2020. Web of Science Citations: 0.
SKAF, MUNIR SALOMAO; POLIKARPOV, IGOR; STANKOVIC, IVANA M. A linker of the proline-threonine repeating motif sequence is bimodal. Journal of Molecular Modeling, v. 26, n. 7 JUN 19 2020. Web of Science Citations: 0.
CORREA, THAILA QUATRINI; BLANCO, KATE CRISTINA; GARCIA, ERICA BOER; LARA PEREZ, SHIRLY MARLENY; CHIANFRONE, DANIEL JOSE; MORAIS, VINICIUS SIGARI; BAGNATO, VANDERLEI SALVADOR. Effects of ultraviolet light and curcumin-mediated photodynamic inactivation on microbiological food safety: A study in meat and fruit. Photodiagnosis and Photodynamic Therapy, v. 30, JUN 2020. Web of Science Citations: 0.
GARCIA, MARLON RODRIGUES; REQUENA, MICHELLE BARRETO; PRATAVIEIRA, SEBASTIAO; MORIYAMA, LILIAN TAN; BECKER, MARCELO; BAGNATO, VANDERLEI SALVADOR; KURACHI, CRISTINA; MAGALHAES, DANIEL VARELA. Development of a system to treat and online monitor photodynamic therapy of skin cancer using PpIX near-infrared fluorescence. Photodiagnosis and Photodynamic Therapy, v. 30, JUN 2020. Web of Science Citations: 0.
JIANG, WENFENG; QU, ZHI-BEI; KUMAR, PRASHANT; VECCHIO, DREW; WANG, YUEFEI; MA, YU; BAHNG, JOONG HWAN; BERNARDINO, KALIL; GOMES, WEVERSON R.; COLOMBARI, FELIPPE M.; LOZADA-BLANCO, ASDRUBAL; VEKSLER, MICHAEL; MARINO, EMANUELE; SIMON, ALEX; MURRAY, CHRISTOPHER; MUNIZ, SERGIO RICARDO; DE MOURA, ANDR F.; KOTOV, NICHOLAS A. Emergence of complexity inhierarchically organized chiral particles. Science, v. 368, n. 6491, SI, p. 642+, MAY 8 2020. Web of Science Citations: 0.
BARRERA-PATINO, C. P.; VOLLET-FILHO, J. D.; TEIXEIRA-ROSA, R. G.; QUIROZ, H. P.; DUSSAN, A.; INADA, N. M.; BAGNATO, V. S.; REY-GONZALEZ, R. R. Photonic effects in natural nanostructures on Morpho cypris and Greta oto butterfly wings. SCIENTIFIC REPORTS, v. 10, n. 1 APR 1 2020. Web of Science Citations: 0.
CARVALHO, KAREN F.; MACHADO, THIAGO S.; GARCIA, BRUNA M.; ZANGIROLAMO, AMANDA F.; MACABELLI, CAROLINA H.; SUGIYAMA, FABRICIA H. C.; GREJO, MATEUS P.; NETO, J. DJACI AUGUSTO; TOSTES, KATIANE; RIBEIRO, FERNANDA K. S.; SARAPIAO, FABIANA D.; PANDEY, ANAND K.; NOCITI, RICARDO P.; TIZIOTO, POLYANA; COUTINHO, LUIZ LEHMAN; MEIRELLES, FLAVIO V.; GUIMARAES, FRANCISCO E. G.; PERNAS, LENA; SENEDA, MARCELO M.; CHIARATTI, MARCOS R. Mitofusin 1 is required for oocyte growth and communication with follicular somatic cells. FASEB JOURNAL, v. 34, n. 6 APR 2020. Web of Science Citations: 1.
REQUENA, MICHELLE BARRETO; RUSSIGNOLI, PEDRO ERNESTO; VOLLET-FILHO, JOSE DIRCEU; SALVIO, ANA GABRIELA; FORTUNATO, THEREZA CURY; PRATAVIEIRA, SEBASTIAO; BAGNATO, VANDERLEI SALVADOR. Use of dermograph for improvement of PpIX precursor's delivery in photodynamic therapy: Experimental and clinical pilot studies. Photodiagnosis and Photodynamic Therapy, v. 29, MAR 2020. Web of Science Citations: 0.
MACHADO, T. R.; LEITE, I. S.; INADA, N. M.; LI, M. S.; DA SILVA, J. S.; ANDRES, J.; BELTRAN-MIR, H.; CORDONCILLO, E.; LONGO, E. Designing biocompatible and multicolor fluorescent hydroxyapatite nanoparticles for cell-imaging applications. MATERIALS TODAY CHEMISTRY, v. 14, DEC 2019. Web of Science Citations: 1.
REQUENA, MICHELLE BARRETO; VOLLET FILHO, JOSE DIRCEU; DE NARDI, ANDRIGO BARBOZA; ESCOBAR, ANDRE; ADAMS, ROZANA DA ROCHA; BAGNATO, VANDERLEI SALVADOR; CAMPOS DE MENEZES, PRISCILA FERNANDA. Topical and intradermal delivery of PpIX precursors for photodynamic therapy with intense pulsed light on porcine skin model. Lasers in Medical Science, v. 34, n. 9, p. 1781-1790, DEC 2019. Web of Science Citations: 0.
DE SOUZA, LARISSA MARILA; INADA, NATALIA MAYUMI; VENTURINI, FRANCINE PERRI; CARMONA-VARGAS, CHRISTIAN C.; PRATAVIEIRA, SEBASTIAO; DE OLIVEIRA, KLEBER THIAGO; KURACHI, CRISTINA; BAGNATO, VANDERLEI SALVADOR. Photolarvicidal effect of curcuminoids from Curcuma longa Linn. against Aedes aegypti larvae. JOURNAL OF ASIA-PACIFIC ENTOMOLOGY, v. 22, n. 1, p. 151-158, MAR 2019. Web of Science Citations: 2.
GONSALVES DE FARIA, CLARA MARIA; INADA, NATALIA MAYUMI; VOLLET-FILHO, JOSE DIRCEU; BAGNATO, VANDERLEI SALVADOR. A threshold dose distribution approach for the study of PDT resistance development A threshold distribution approach for the study of PDT resistance. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 182, p. 85-91, MAY 2018. Web of Science Citations: 1.
FERREIRA BORDINI, ESTER ALVES; TONON, CAROLINE CORADI; FRANCISCONI, RENATA SERIGNOLI; CINTRA MAGALHAES, FERNANDO AUGUSTO; MAQUERA HUACHO, PATRICIA MILAGROS; BEDRAN, TELMA LOMBARDO; PRATAVIEIRA, SEBASTIAO; SPOLIDORIO, LUIS CARLOS; SPOLIDORIO, DENISE PALOMARI. Antimicrobial effects of terpinen-4-ol against oral pathogens and its capacity for the modulation of gene expression. BIOFOULING, v. 34, n. 7, p. 815-825, 2018. Web of Science Citations: 1.
MAQUERA-HUACHO, PATRICIA MILAGROS; TONON, CAROLINE CORADI; CORREIA, MARILIA FERREIRA; FRANCISCONI, RENATA SERIGNOLI; FERREIRA BORDINI, ESTER ALVES; MARCANTONIO, ELCIO; PALOMARI SPOLIDORIO, DENISE MADALENA. In vitro antibacterial and cytotoxic activities of carvacrol and terpinen-4-ol against biofilm formation on titanium implant surfaces. BIOFOULING, v. 34, n. 6, p. 699-709, 2018. Web of Science Citations: 1.
ROMANO, RENAN A.; PRATAVIEIRA, SEBASTIAO; DA SILVA, ANA P.; KURACHI, CRISTINA; GUIMARAES, FRANCISCO E. G. Light-driven photosensitizer uptake increases Candida albicans photodynamic inactivation. Journal of Biophotonics, v. 10, n. 11, SI, p. 1538-1546, NOV 2017. Web of Science Citations: 6.
DECARLI, M. C.; CORREA, T. Q.; VOLLET-FILHO, J. D.; BAGNATO, V. S.; SOUZA, C. W. O. The influence of experimental conditions on the final result of photoinhibition of Staphylococcus aureus. Photodiagnosis and Photodynamic Therapy, v. 19, p. 229-234, SEP 2017. Web of Science Citations: 1.
SADRAEIAN, MOHAMMAD; GUIMARAES, FRANCISCO E. G.; ARAUJO, ANA P. U.; WORTHYLAKE, DAVID K.; LECOUR, LOUIS JR.; PINCUS, SETH H. Selective cytotoxicity of a novel immunotoxin based on pulchellin A chain for cells expressing HIV envelope. SCIENTIFIC REPORTS, v. 7, AUG 8 2017. Web of Science Citations: 2.
CASTILLO PEDRAZA, MIDIAN C.; NOVAIS, TATIANA F.; FAUSTOFERRI, ROBERTA C.; QUIVEY, JR., ROBERT G.; TEREKHOV, ANTON; HAMAKER, BRUCE R.; KLEIN, MARLISE I. Extracellular DNA and lipoteichoic acids interact with exopolysaccharides in the extracellular matrix of Streptococcus mutans biofilms. BIOFOULING, v. 33, n. 9, p. 722-740, 2017. Web of Science Citations: 11.
ROSSETO, FLAVIO RODOLFO; MANZINE, LIVIA REGINA; NETO, MARIO DE OLIVEIRA; POLIKARPOV, IGOR. Biophysical and biochemical studies of a major endoglucanase secreted by Xanthomonas campestris pv. campestris.. Enzyme and Microbial Technology, v. 91, p. 1-7, SEP 2016. Web of Science Citations: 2.
SEIKI KADOWAKI, MARCO ANTONIO; CAMILO, CESAR MOISES; MUNIZ, AMANDA BERNARDES; POLIKARPOV, IGOR. Functional Characterization and Low-Resolution Structure of an Endoglucanase Cel45A from the Filamentous Fungus Neurospora crassa OR74A: Thermostable Enzyme with High Activity Toward Lichenan and beta-Glucan. MOLECULAR BIOTECHNOLOGY, v. 57, n. 6, p. 574-588, JUN 2015. Web of Science Citations: 7.
ELLENA, JAVIER; DE PAULA, KARINA; DE MELO, CRISTIANE C.; DA SILVA, CECILIA C. P.; BEZERRA, BEATRIZ P.; VENANCIO, TIAGO; AYALA, ALEJANDRO P. Temperature-Driven Isosymmetric Reversible Phase Transition of the Hormone Estradiol 17 beta Valerate. Crystal Growth & Design, v. 14, n. 11, p. 5700-5709, NOV 2014. Web of Science Citations: 8.
RUSSO, MARCOS G.; BRUSAU, ELENA V.; ELLENA, JAVIER; NARDA, GRISELDA E. Solid-State Supramolecular Synthesis Based on the N-H center dot center dot center dot O Heterosynthon: An Approach to Solve the Polymorphism Problem in Famotidine. Journal of Pharmaceutical Sciences, v. 103, n. 11, p. 3754-3763, NOV 2014. Web of Science Citations: 2.
CAMILO, CESAR M.; POLIKARPOV, IGOR. High-throughput cloning, expression and purification of glycoside hydrolases using Ligation-Independent Cloning (LIC). Protein Expression and Purification, v. 99, p. 35-42, JUL 2014. Web of Science Citations: 21.
LIMA, MARISA A.; OLIVEIRA-NETO, MARIO; KADOWAKI, MARCO ANTONIO S.; ROSSETO, FLAVIO R.; PRATES, ERICA T.; SQUINA, FABIO M.; LEME, ADRIANA F. P.; SKAF, MUNIR S.; POLIKARPOV, IGOR. Aspergillus niger beta-Glucosidase Has a Cellulase-like Tadpole Molecular Shape INSIGHTS INTO GLYCOSIDE HYDROLASE FAMILY 3 (GH3) beta-GLUCOSIDASE STRUCTURE AND FUNCTION. Journal of Biological Chemistry, v. 288, n. 46, p. 32991-33005, NOV 15 2013. Web of Science Citations: 27.
PRATES, ERICA T.; STANKOVIC, IVANA; SILVEIRA, RODRIGO L.; LIBERATO, MARCELO V.; HENRIQUE-SILVA, FLAVIO; PEREIRA, JR., NEI; POLIKARPOV, IGOR; SKAF, MUNIR S. X-ray Structure and Molecular Dynamics Simulations of Endoglucanase 3 from Trichoderma harzianum: Structural Organization and Substrate Recognition by Endoglucanases That Lack Cellulose Binding Module. PLoS One, v. 8, n. 3 MAR 14 2013. Web of Science Citations: 18.
TEXTOR, LARISSA C.; COLUSSI, FRANCIELI; SILVEIRA, RODRIGO L.; SERPA, VIVIANE; DE MELLO, BRUNO L.; MUNIZ, JOAO RENATO C.; SQUINA, FABIO M.; PEREIRA, JR., NEI; SKAF, MUNIR S.; POLIKARPOV, IGOR. Joint X-ray crystallographic and molecular dynamics study of cellobiohydrolase I from Trichoderma harzianum: deciphering the structural features of cellobiohydrolase catalytic activity. FEBS Journal, v. 280, n. 1, p. 56-69, JAN 2013. Web of Science Citations: 32.
TRIVELLA, DANIELA B. B.; DOS REIS, CAIO V.; LIMA, LUIS MAURICIO T. R.; FOGUEL, DEBORA; POLIKARPOV, IGOR. Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis. Journal of Structural Biology, v. 180, n. 1, p. 143-153, OCT 2012. Web of Science Citations: 24.
COLUSSI, FRANCIELI; GARCIA, WANIUS; ROSSETO, FLAVIO RODOLFO; SOARES DE MELLO, BRUNO LUAN; DE OLIVEIRA NETO, MARIO; POLIKARPOV, IGOR. Effect of pH and temperature on the global compactness, structure, and activity of cellobiohydrolase Cel7A from Trichoderma harzianum. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, v. 41, n. 1, p. 89-98, JAN 2012. Web of Science Citations: 13.

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