Transcranial direct current stimulation modulates ERP-indexed inhibitory control and reduces food consumption

Autor(es)

Lapenta, Olivia Morgan ^[1] ; Di Sierve, Karina ^[1] ; de Macedo, Elizeu Coutinho ^[1] ; Fregni, Felipe ^{[2, 3]} ; Boggio, Paulo Sergio ^[1]

Afiliação do(s) autor(es)

^[1] Univ Prebiteriana Mackenzie, Ctr Hlth & Biol Sci, Social & Cognit Neurosci Lab & Dev Disorders Prog, Sao Paulo - Brazil

^[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA - USA

^[3] Harvard Univ, Sch Med, Spaulding Neuromodulat Ctr, Spaulding Rehabil Hosp, Boston, MA - USA

• Tipo de documento: Artigo Científico
• Fonte: APPETITE; v. 83, p. 42-48, DEC 1 2014.
• Citações Web of Science: 56

Resumo

Food craving can be defined as the ``urge to eat a specific food{''}. Previous findings suggest impairment of inhibitory control, specifically a regulatory deficit in the lateral prefrontal circuitry that is associated with a compulsion for food. As demonstrated by three previous studies, bilateral transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) (anode right/cathode left) reduces food craving and caloric intake. We designed the present study to evaluate the neural mechanisms that underlie these effects. We replicated the design of one of these previous studies but included electroencephalographic assessments to register evoked potentials in a Go/No-go task that contained pictures of food and furniture (a control visual stimulus). We collected data from nine women (mean age = 23.4 +/- 2 years) in a crossover experiment. We observed that active DLPFC tDCS (anode right/cathode left), compared with sham stimulation, reduced the frontal N2 component and enhanced the P3a component of responses to No-go stimuli, regardless of the stimulus condition (food or furniture). Active tDCS was also associated with a reduction in caloric intake. We discuss our findings in the context of cortico-subcortical processing of craving and tDCS effects on inhibitory control neural circuitry. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 12/24696-1 - A importância da rede cortical motora na percepção de movimentos humanos
• Beneficiário: Olivia Morgan Lapenta
• Modalidade de apoio: Bolsas no Brasil - Doutorado