The relationship between ezrin and podoplanin expressions in keratocystic odontogenic tumors

Autor(es)

Oliveira, Denise Tostes ^[1] ; de Santis, Lais Priscila ^[1] ; Assao, Agnes ^[1] ; Tjioe, Kellen Cristine ^[1] ; Nonogaki, Suely ^[2] ; Pereira Lauris, Jose Roberto ^[3] ; Soares, Fernando Augusto ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP - Brazil

^[2] Adolfo Lutz Inst, Div Pathol, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Bauru Sch Dent, Dept Community Dent, BR-17012901 Bauru, SP - Brazil

^[4] AC Camargo Canc Hosp, Dept Pathol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BMC ORAL HEALTH; v. 14, DEC 5 2014.
• Citações Web of Science: 5

Resumo

Background: The aims of this study were to investigate the immunolocalization of ezrin and its relationship with the podoplanin expression in keratocystic odontogenic tumors. Material and Methods: The immunohistochemical expressions of ezrin and podoplanin by odontogenic epithelium were evaluated in keratocystic odontogenic tumors using monoclonal antibodies. Results: Our results showed strong cytoplasmic ezrin and membranous podoplanin expressions in basal epithelial layer of all keratocystic odontogenic tumors. The cytoplasmic and membranous ezrin expressions were also detected in suprabasal epithelial layers of tumors. Statistically significant difference between cellular immunolocalization of ezrin and podoplanin odontogenic epithelium were found by Wilcoxon's test (p < 0.05). No correlation between both proteins in keratocystic odontogenic tumors was detected by Spearman test. Conclusions: These results suggest that ezrin and podoplanin may contribute to the expansive growth and local invasiveness of keratocystic odontogenic tumors. Additionally, as both proteins were overexpressed by odontogenic epithelium, their possible roles need to be further explored in benign odontogenic tumors. (AU)

• Processo FAPESP: 12/13411-6 - Participação da podoplanina no processo de remodelação celular em tumores odontogênicos benignos e tumores epiteliais malignos de boca
• Beneficiário: Denise Tostes Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/16999-7 - Correlação da expressão da podoplanina, ezrin e Rho-A em carcinomas espinocelulares de lábio inferior
• Beneficiário: Agnes Assao
• Modalidade de apoio: Bolsas no Brasil - Mestrado