Elevated CETP activity during acute phase of myocardial infarction is independently associated with endothelial dysfunction and adverse clinical outcome

Autor(es):Mostrar menos -

Carvalho, Luiz Sergio F. ^[1] ; Virginio, Vitor W. M. ^{[1, 2]} ; Panzoldo, Natalia B. ^{[1, 2]} ; Figueiredo, Valeria N. ^[1] ; Santos, Simone N. ^[1] ; Modolo, Rodrigo G. P. ^[1] ; Andrade, Joalbo M. ^[3] ; Quinaglia e Silva, Jose C. ^[4] ; Nadruz-Junior, Wilson ^[1] ; de Faria, Eliana C. ^[2] ; Sposito, Andrei C. ^[1] ; Grp, Brasilia Heart Study

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Sch Med, Div Cardiol, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, UNICAMP, Sch Med, Lipids Lab, Campinas, SP - Brazil

^[3] Univ Brasilia, Brasilia, DF - Brazil

^[4] Escola Super Ciencias Saude, Brasilia, DF - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ATHEROSCLEROSIS; v. 237, n. 2, p. 777-783, DEC 2014.
• Citações Web of Science: 13

Resumo

Objective: Recent data suggests that cholesteryl ester transfer protein (CETP) activity may interact with acute stress conditions via inflammatory-oxidative response and thrombogenesis. We investigated this assumption in patients with ST-elevation myocardial infarction (STEMI). Methods: Consecutive patients with STEMI (n = 116) were enrolled <24-h of symptoms onset and were followed for 180 days. Plasma levels of C-reactive protein (CRP), interleukin-2 (IL-2), tumor necrosis factor (TNF alpha), 8-isoprostane, nitric oxide (NOx) and CETP activity were measured at enrollment (D1) and at fifth day (D5). Flow-mediated dilation (FMD) was assessed by ultrasound and coronary thrombus burden (CTB) was evaluated by angiography. Results: Neither baseline nor the change of CETP activity from D1 to D5 was associated with CRP, IL-2, TNF alpha, 8-isoprostane levels or CTB. The rise in NOx from D1 to D5 was inferior {[}3.5(-1; 10) vs. 5.5(-1; 12); p < 0.001] and FMD was lower {[}5.9(5.5) vs. 9.6(6.6); p = 0.047] in patients with baseline CETP activity above the median value than in their counterparts. Oxidized HDL was measured by thiobarbituric acid reactive substances (TBARS) in isolated HDL particles and increased from D1 to D5, and remaining elevated at D30. The change in TBARS content in HDL was associated with CETP activity (r = 0.72; p = 0.014) and FMD (r = -0.61; p = 0.046). High CETP activity at admission was associated with the incidence of sudden death and recurrent MI at 30 days (OR 12.8; 95% CI 1.25-132; p = 0.032) and 180 days (OR 3.3; 95% CI 1.03-10.7; p = 0.044). Conclusions: An enhanced CETP activity during acute phase of STEMI is independently associated with endothelial dysfunction and adverse clinical outcome. (C) 2014 Elsevier Ireland Ltd. All rights reserved. (AU)

• Processo FAPESP: 12/18044-1 - Efeito do tratamento com niacina sobre o metabolismo do HDL e a função endotelial em pacientes com HDL baixo com ou sem Hipertrigliceridemia.
• Beneficiário: Valéria Nasser Figueiredo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado