| Texto completo | |
| Autor(es): |
Tavares Novo, Marilia Campos
[1]
;
Osugui, Lika
[1]
;
dos Reis, Vanessa Oliveira
[1]
;
Longo-Maugeri, Ieda Maria
[1]
;
Mariano, Mario
[1]
;
Popi, Ana Flavia
[1]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Fed Sao Paulo, UNIFESP, Dept Microbiol Imunol & Parasitol, Disciplina Imunol, BR-04023900 Sao Paulo - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Immunobiology; v. 220, n. 1, p. 60-67, JAN 2015. |
| Citações Web of Science: | 20 |
| Resumo | |
The Wnt/beta-catenin signaling pathway has been shown to play an important role in controlling the proliferation, survival and differentiation of hematopoietic cells. Several Wnt/beta-catenin signaling components influence hematopoietic cells fate. B-1 cells are self-renewing and spontaneously express both myeloid and lymphoid restricted transcription factors. B-1 lymphocytes play a major role in autoimmunity and are related to CD5(+) B-cell lymphomas and leukemias, such as CLL (chronic lymphocytic leukemia). Herein, we demonstrate that Wnt/beta-catenin pathway is important to B-1 cell survival in vitro. The loss of Wnt signals by quercetin treatment induces a reduction in the proliferation and survival of B-1 cells. Furthermore, the quercetin treatment diminishes IL-6 production by peritoneal cells, a cytokine important to the maintenance of B-1 cells in vitro. Importantly, the IL-6 addition to B-1 cell culture prevents cells from apoptosis, even in the presence of quercetin. These data suggest that a deregulation in beta-catenin signals could result in alterations in B-1 cell proliferation and differentiation. The correlation between Wnt/beta-catenin and IL-6 could point out a mechanism for the expansion of B-1 cells in autoimmune disease and neoplasia. (C) 2014 Elsevier GmbH. All rights reserved. (AU) | |
| Processo FAPESP: | 08/55526-9 - Participacao da via wnt/beta-catenina na diferenciacao e auto-renovacao de celulas b-1. |
| Beneficiário: | Ana Flavia Popi |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 08/58561-0 - Celulas b-1 na embriologia, diferenciacao e imunomodulacao |
| Beneficiário: | Mario Mariano |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |