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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The Influence of genetic factors on peripartum depression: A systematic review

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Autor(es):
Figueiredo, Felipe Pinheiro [1] ; Parada, Ana Paula [1] ; de Araujo, Luiza Ferreira [2] ; Silva, Jr., Wilson Araujo [2] ; Del-Ben, Cristina Marta [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav, BR-05508 Sao Paulo - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Genet, BR-05508 Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: Journal of Affective Disorders; v. 172, p. 265-273, FEB 1 2015.
Citações Web of Science: 17
Resumo

Background: This systematic review aimed to explore the potential influence of genetic factors on the symptoms of peripartum depression and to critically analyze the methodologies employed by the examined studies. Methods: A systematic review of the literature indexed prior to July 2014 identified 200 articles. After applying the inclusion and exclusion criteria, 39 papers were included. Results: The papers predominantly featured a molecular genetic approach (n=35), and the majority examined polymorphisms (n=27). Most studies used samples of Caucasians living in high income countries. The results suggest that the influence of genetic factors become more consistent when methodological variations among the studies are considered. Environmental stressors are also important variables that influence the relationship between genetic factors and peripartum depressive states. In addition, differences in the influence of genetic factors were observed depending upon the precise time point during pregnancy or the postpartum period that was examined in the studies. The late stages of pregnancy and the early postpartum period were Limes of greater genetic vulnerability. Limitations: This study was limited by the small number of papers reviewed and by the lack of information regarding whether the effects of genetics on peripartum depression are specific to certain ethnicities and/or stressors. Conclusions: Genetic studies of perinatal depression reinforce a pathophysiological role of the hormonal changes inherent in the childbirth period. However, the distinction between depressive episodes that begin during pregnancy from those that begin during the postpartum period can still be useful to improve our understanding of the physiopathology of depressive disorders. (C) 2014 Elsevier B.V, All rights reserved. (AU)

Processo FAPESP: 10/09066-6 - Interação genético-ambiental nos estados depressivos pós-parto
Beneficiário:Cristina Marta Del-Ben
Modalidade de apoio: Auxílio à Pesquisa - Regular