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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopause

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Autor(es):
Conti, Filipe Fernandes [1] ; Brito, Janaina de Oliveira [1] ; Bernardes, Nathalia [2] ; Dias, Danielle da Silva [1] ; Sanches, Iris Callado [1] ; Malfitano, Christiane [1] ; Francisca Llesuy, Susana [3] ; Irigoyen, Maria-Claudia [2] ; de Angelis, Katia [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Nove de Julho UNINOVE, Lab Translat Physiol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Heart Inst InCor, Sch Med, Hypertens Unit, Sao Paulo - Brazil
[3] Univ Buenos Aires, Fac Farm & Bioquim, Dept Quim Analit & Fisicoquim, RA-1113 Buenos Aires, DF - Argentina
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: BMC CARDIOVASCULAR DISORDERS; v. 14, DEC 11 2014.
Citações Web of Science: 14
Resumo

Background: Metabolic syndrome is characterized by the association of 3 or more risk factors, including: abdominal obesity associated with an excess of abdominal fat, insulin resistance, type 2 diabetes, dyslipidemia and hypertension. Moreover, the prevalence of hypertension and metabolic dysfunctions sharply increases after the menopause. However, the mechanisms involved in these changes are not well understood. Thus, the aim of this study was to assess the effects of fructose overload on cardiovascular autonomic modulation, inflammation and cardiac oxidative stress in an experimental model of hypertension and menopause. Methods: Female SHR rats were divided into (n = 8/group): hypertensive (H), hypertensive ovariectomized (HO) and hypertensive ovariectomized undergoing fructose overload (100 g/L in drinking water) (FHO). Arterial pressure (AP) signals were directly recorded. Cardiac autonomic modulation was evaluated by spectral analysis. Oxidative stress was evaluated in cardiac tissue. Results: AP was higher in the FHO group when compared to the other groups. Fructose overload promoted an increase in body and fat weight, triglyceride concentration and a reduction in insulin sensitivity. IL-10 was reduced in the FHO group when compared to the H group. TNF-alpha was higher in the FHO when compared to all other groups. Lipoperoxidation was higher and glutathione redox balance was reduced in the FHO group when compared to other groups, an indication of increased oxidative stress. A negative correlation was found between IL-10 and adipose tissue. Conclusion: Fructose overload promoted an impairment in cardiac autonomic modulation associated with inflammation and oxidative stress in hypertensive rats undergoing ovarian hormone deprivation. (AU)

Processo FAPESP: 11/15828-9 - Efeitos do treinamento físico combinado em modelo experimental de disfunções cardiometabólicas associadas à privação dos hormônios ovarianos.
Beneficiário:Filipe Fernandes Conti
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 12/20141-5 - Efeitos do treinamento físico aeróbio, resistido ou combinado em modelos experimentais de disfunções cardiometabólicas associadas à privação dos hormônios ovarianos
Beneficiário:Kátia de Angelis Lobo D Avila
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 10/17188-4 - Mecanismos associados às disfunções em um modelo experimental de menopausa e síndrome metabólica: papel do treinamento físico aeróbio ou resistido
Beneficiário:Janaina de Oliveira Brito
Linha de fomento: Bolsas no Brasil - Doutorado