Long-term increased factor VIII levels are associated to interleukin-6 levels but not to post-thrombotic syndrome in patients with deep venous thrombosis

Autor(es)

Bittar, Luis Fernando ^[1] ; Mazetto, Bruna de Moraes ^[1] ; Orsi, Fernanda L. Andrade ^[1] ; Collela, Marina P. ^[1] ; De Paula, Erich Vinicius ^[1] ; Annichino-Bizzacchi, Joyce M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Hematol & Hemotherapy Ctr, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: THROMBOSIS RESEARCH; v. 135, n. 3, p. 497-501, MAR 2015.
• Citações Web of Science: 13

Resumo

Introduction: Increased FVIII levels are a well established risk factor for deep venous thrombosis (DVT), whose etiopathogenesis is not yet well understood. In this study, we aimed to evaluate the possibility that inflammatory markers and post-thrombotic syndrome (PTS) could contribute to FVIII levels in patients with a history of DVT. Design and Methods: It is a case-control study that included 68 patients with DVT of the lower limbs 32 months after the acute episode, and 67 healthy adults as controls. We evaluated plasma levels of FVIII, VWF, D-dimer and serum levels of CRP, IL-6, IL-8, TNF-alpha in patients and controls. The presence of PTS was evaluated by the Villalta scale. Results: Patients with DVT presented higher levels of FVIII, VWF and D-dimer when compared to controls (P <= 0.001). Almost 50% of patients presented FVIII levels above 90th percentile. Furthermore, IL-6 (1.19 vs. 0.98 pg/mL, P = 0.01) and TNF-alpha (2.27 vs. 1.57 pg/mL, P <= 0.001) were also higher in patients when compared to controls. In a linear regression multivariate model, VWF and IL-6 levels were independent factors associated with FVIII levels (P <= 0.001). FVIII levelswere not increased in patients with PTS. Patients with PTS showed higher levels of IL-8 when compared to patients without PTS (23.03 vs. 18.20 pg/mL, P = 0.04). Conclusions: In conclusion, we demonstrated that DVT is associated with increased levels of inflammatory and coagulation markers, including FVIII, even a long time after the acute episode. Moreover, IL-6 levels were an independent factor associated with FVIII levels. Finally, PTS seems to be related to inflammatory cytokine IL-8, a proinflammatory and proangiogenic chemokine, but not to FVIII levels. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 09/53543-6 - Avaliacao da expressao genica do receptor hepatico lrp e do fator viii e sua correlacao com os niveis plasmaticos de fator viii e fator de von willebrand.
• Beneficiário: Luis Fernando Bittar Sckayer
• Modalidade de apoio: Bolsas no Brasil - Doutorado