Key participants of the tumor microenvironment of the prostate: An approach of the structural dynamic of cellular elements and extracellular matrix components during epithelial-stromal transition

Autor(es)

Goncalves, Bianca F. ^[1] ; de Campos, Silvana G. P. ^[2] ; Costa, Carolina F. P. ^[1] ; Scarano, Wellerson R. ^[3] ; Goes, Rejane M. ^[2] ; Taboga, Sebastiao R. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Dept Struct & Funct Biol, Inst Biol, BR-13083864 Campinas, SP - Brazil

^[2] Sao Paulo State Univ, Humanities & Exact Sci UNESP IBILCE, Dept Biol, Inst Biosci, Lab Microscopy & Microanal, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

^[3] Sao Paulo State Univ, Dept Morphol, Inst Biosci, BR-18618000 Botucatu, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: ACTA HISTOCHEMICA; v. 117, n. 1, p. 4-13, 2015.
• Citações Web of Science: 7

Resumo

Cancer is a multistep process that begins with the transformation of normal epithelial cells and continues with tumor growth, stromal invasion and metastasis. The remodeling of the peritumoral environment is decisive for the onset of tumor invasiveness. This event is dependent on epithelial stromal interactions, degradation of extracellular matrix components and reorganization of fibrillar components. Our research group has studied in a new proposed rodent model the participation of cellular and molecular components in the prostate microenvironment that contributes to cancer progression. Our group adopted the gerbil Meriones unguiculatus as an alternative experimental model for prostate cancer study. This model has presented significant responses to hormonal treatments and to development of spontaneous and induced neoplasias. The data obtained indicate reorganization of type I collagen fibers and reticular fibers, synthesis of new components such as tenascin and proteoglycans, degradation of basement membrane components and elastic fibers and increased expression of metalloproteinases. Fibroblasts that border the region, apparently participate in the stromal reaction. The roles of each of these events, as well as some signaling molecules, participants of neoplastic progression and factors that promote genetic reprogramming during epithelial stromal transition are also discussed. (C) 2014 Elsevier GmbH. All rights reserved. (AU)

• Processo FAPESP: 08/11236-7 - Carcinogênese prostática quimicamente induzida por N-metil N-nitrosuréia (MNU) em gerbilos da Mongólia: associação com promotores esteroides ou dieta hiperlipídica
• Beneficiário: Bianca Facchim Gonçalves
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto