Hippocampal serotonin depletion is related to the presence of generalized tonic-clonic seizures, but not to psychiatric disorders in patients with temporal lobe epilepsy

Autor(es)

da Fonseca, Natascha C. ^[1] ; Joaquim, Helena P. G. ^[2] ; Talib, Leda L. ^[2] ; de Vincentiis, Silvia ^{[1, 3]} ; Gattaz, Wagner F. ^[2] ; Valente, Kette D. ^{[1, 3, 4]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Hosp Clin, Inst Psychiat, Lab Clin Neurophysiol, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Sch Med, Hosp Clin, Inst Psychiat, Lab Neurosci, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Sch Med, Hosp Clin, Inst Psychiat, Lab Neuroimaging, Sao Paulo, SP - Brazil

^[4] Univ Sao Paulo, Ctr Support Res Appl Neurosci, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Epilepsy Research; v. 111, p. 18-25, MAR 2015.
• Citações Web of Science: 9

Resumo

Objective: Previous studies suggest that concentration of serotonin ({[}5-HT]) plays a pathogenic role in various types of epilepsy inhibiting seizures. However, most have not considered the clinical variables of epilepsy, and all of these studies included small and heterogeneous samples with refractory epilepsy, regardless of etiology. In this work, we measured {[}5-HT]s in hippocampal tissues from a large series of patients with refractory temporal lobe epilepsy caused by hippocampal sclerosis who underwent epilepsy surgery and evaluated the relationship between {[}5HT] and epilepsy-related clinical variables and psychiatric disorders. Methods: We included 44 patients with refractory unilateral TLE-HS who underwent surgical treatment for epilepsy. Hippocampal samples were collected, and serotonin concentrations were measured with high-pressure liquid chromatography (HPLC). Results: Lower {[}5-HT]s were correlated with a history of GTC seizures (Student's t-test: p0.041). There were no differences in {[}5-HT]s according to the other clinical variables and the presence of psychiatric disorders. Significance: Our findings demonstrated that serotonin depletion in the hippocampus play an important role in some aspects of the severity of epilepsy (i.e., the presence of GTC seizures) in a homogeneous sample of patients with refractory temporal lobe epilepsy determined by hippocampal sclerosis, but not with the presence of psychiatric disorders. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 13/11361-4 - Estudo de associação entre polimorfismos de genes da via serotoninérgica e epilepsia do lobo temporal causada por esclerose hipocampal
• Beneficiário: Kette Dualibi Ramos Valente
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 05/56464-9 - Centro de Imagem em Neurociências da Faculdade de Medicina da Universidade de São Paulo
• Beneficiário: Giovanni Guido Cerri
• Modalidade de apoio: Auxílio à Pesquisa - Programa CINAPCE - Temático