Aryl carboxylic acid reduction and further reactions with GABA and glucose promoted by whole cells of Xylaria arbuscula

Autor(es)

Amaral, Luciana da Silva ^[1] ; Rodrigues-Filho, Edson ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC; v. 113, p. 90-94, MAR 2015.
• Citações Web of Science: 6

Resumo

Xylaria arbuscula was collected from a ``Cypress{''} tree, Cupressus lusitanica. The whole cells of this endophytic fungus were used in screening for microbial bioreduction of aryl acids. Different p-substituted benzoic acids were evaluated. However, only p-bromobenzoic acid, p-chlorobenzoic acid and p-nitrobenzoic acid were converted to their corresponding alcohols. Aryl acid metabolism of X. arbuscula included GABA incorporation and glycosylation when the substrates were p-bromobenzoic and p-chlorobenzoic acids were also observed. The substrates p-hydroxybenzoic and p-aminobenzoic acids were not transformed. These results could suggest that electron-withdrawing groups at para orientation activate the substrate for reduction. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 10/11384-6 - Biotransformação de produtos naturais e sintéticos utilizando micro-organismos endofíticos, uma abordagem quimio-ecológica para a produção de substâncias bioativas
• Beneficiário: Edson Rodrigues Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/18603-3 - Estudos metabolômicos e biossintéticos visando contribuições para a química e taxonomia de micro-organismos da família Xylariaceae
• Beneficiário: Luciana da Silva Amaral
• Modalidade de apoio: Bolsas no Brasil - Doutorado