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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Aryl carboxylic acid reduction and further reactions with GABA and glucose promoted by whole cells of Xylaria arbuscula

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Author(s):
Amaral, Luciana da Silva [1] ; Rodrigues-Filho, Edson [1]
Total Authors: 2
Affiliation:
[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC; v. 113, p. 90-94, MAR 2015.
Web of Science Citations: 6
Abstract

Xylaria arbuscula was collected from a ``Cypress{''} tree, Cupressus lusitanica. The whole cells of this endophytic fungus were used in screening for microbial bioreduction of aryl acids. Different p-substituted benzoic acids were evaluated. However, only p-bromobenzoic acid, p-chlorobenzoic acid and p-nitrobenzoic acid were converted to their corresponding alcohols. Aryl acid metabolism of X. arbuscula included GABA incorporation and glycosylation when the substrates were p-bromobenzoic and p-chlorobenzoic acids were also observed. The substrates p-hydroxybenzoic and p-aminobenzoic acids were not transformed. These results could suggest that electron-withdrawing groups at para orientation activate the substrate for reduction. (C) 2015 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 10/11384-6 - Biotransformation of natural and synthetic products using endophytic microorganisms, a chemical-ecologycal approach for the production of bioactive substances
Grantee:Edson Rodrigues Filho
Support Opportunities: Regular Research Grants
FAPESP's process: 13/18603-3 - Metabolic and biosynthetic studies for the chemical and taxonomic contribution of Xylariaceae family microorganisms
Grantee:Luciana da Silva Amaral
Support Opportunities: Scholarships in Brazil - Doctorate