Association of mesenchymal stem cells and osteoblasts for bone repair

Autor(es)

Santos, Thiago de Santana ^[1] ; Flores Abuna, Rodrigo Paolo ^[1] ; Lopes, Helena Bacha ^[1] ; Goncalves de Almeida, Adriana Luisa ^[1] ; Beloti, Marcio Mateus ^[1] ; Rosa, Adalberto Luiz ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Cell Culture Lab, Sch Dent Ribeirao Preto, BR-14040904 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Dept Oral & Maxillofacial Surg & Periodontol, Sch Dent Ribeirao Preto, BR-14040904 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: REGENERATIVE MEDICINE; v. 10, n. 2, p. 127-133, 2015.
• Citações Web of Science: 6

Resumo

Aim: We tested the hypothesis that the association of bone marrow mesenchymal stem cells (MSCs) and osteoblasts (OBs) optimize bone repair. Materials \& Methods: MSCs were cultured in growth or osteogenic medium and seeded into gelatin sponge prior to implantation. Defects were created into rat calvariae and implanted with gelatin sponge without cells, with MSCs, with OBs and with association of MSCs and OBs. Histological analysis and micro-CT-based histomorphometry were carried out after 4 weeks. Results: Increased bone formation was observed in defects treated with cells and bone volume was greater in defects treated with either OBs or MSCs/OBs. Conclusion: Association of MSCs and OBs did not increase the process of bone repair compared with cell-based therapy using either MSCs or OBs alone. (AU)

• Processo FAPESP: 11/00919-9 - Efeitos da terapia celular com a associação de células-tronco mesenquimais e osteoblastos no reparo do tecido ósseo
• Beneficiário: Thiago de Santana Santos
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 11/00617-2 - Efeitos da terapia celular com a associação de células-tronco mesenquimais e osteoblastos no reparo do tecido ósseo
• Beneficiário: Adalberto Luiz Rosa
• Modalidade de apoio: Auxílio à Pesquisa - Regular