Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium

Autor(es):Mostrar menos -

Toporcov, Tatiana Natasha ^[1] ; Znaor, Ariana ^[2] ; Zhang, Zuo-Feng ^[3] ; Yu, Guo-Pei ^{[4, 5]} ; Winn, Deborah M. ^[6] ; Wei, Qingyi ^[7] ; Vilensky, Marta ^[8] ; Vaughan, Thomas ^[9] ; Thomson, Peter ^[10] ; Talamini, Renato ^[11] ; Szeszenia-Dabrowska, Neonila ^[12] ; Sturgis, Erich M. ^[7] ; Smith, Elaine ^[13] ; Shangina, Oxana ^[14] ; Schwartz, Stephen M. ^[9] ; Schantz, Stimson ^[15] ; Rudnai, Peter ^[16] ; Richiardi, Lorenzo ^[17] ; Ramroth, Heribert ^[18] ; Purdue, Mark P. ^[6] ; Olshan, Andrew F. ^[19] ; Eluf-Neto, Jose ^[20] ; Muscat, Joshua ^[21] ; Moyses, Raquel Ajub ^[22] ; Morgenstern, Hal ^{[23, 24, 25]} ; Menezes, Ana ^[26] ; McClean, Michael ^[27] ; Matsuo, Keitaro ^[28] ; Mates, Dana ^[29] ; Macfarlane, Tatiana V. ^[30] ; Lissowska, Jolanta ^{[31, 32]} ; Levi, Fabio ^{[33, 34]} ; Lazarus, Philip ^[35] ; La Vecchia, Carlo ^{[36, 37]} ; Lagiou, Pagona ^[38] ; Koifman, Sergio ^[39] ; Kjaerheim, Kristina ^[40] ; Kelsey, Karl ^[41] ; Holcatova, Ivana ^[42] ; Herrero, Rolando ^[43] ; Healy, Claire ^[44] ; Hayes, Richard B. ^[45] ; Franceschi, Silvia ^[46] ; Fernandez, Leticia ^[47] ; Fabianova, Eleonora ^[48] ; Daudt, Alexander W. ^[49] ; Curioni, Otavio Alberto ^[50] ; Dal Maso, Luigino ^[11] ; Curado, Maria Paula ^[51] ; Conway, David I. ^[52] ; Chen, Chu ; Castellsague, Xavier ^[53] ; Canova, Cristina ^[54] ; Cadoni, Gabriella ^[55] ; Brennan, Paul ^[49] ; Boccia, Stefania ^[56] ; Antunes, Jose Leopoldo Ferreira ^[1] ; Ahrens, Wolfgang ^{[57, 58]} ; Agudo, Antonio ^[59] ; Boffetta, Paolo ^[60] ; Hashibe, Mia ^[61] ; Lee, Yuan-Chin Amy ^[62] ; Wuensch Filho, Victor ^[1]

Afiliação do(s) autor(es):Mostrar menos -

^[1] Univ Sao Paulo, Fac Saude Publ, BR-01246904 Sao Paulo, SP - Brazil

^[2] Croatian Natl Canc Registry, Zagreb - Croatia

^[3] Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 - USA

^[4] Peking Univ, Med Informat Ctr, Beijing 100871 - Peoples R China

^[5] New York Med Coll, Valhalla, NY 10595 - USA

^[6] NCI, Bethesda, MD 20892 - USA

^[7] UT MD Anderson Canc Ctr, Houston, TX - USA

^[8] Univ Buenos Aires, Inst Oncol Angel H Roffo, Buenos Aires, DF - Argentina

^[9] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 - USA

^[10] Univ Newcastle, Sch Dent Sci, Newcastle Upon Tyne, Tyne & Wear - England

^[11] Aviano Canc Ctr, I-33081 Aviano - Italy

^[12] Inst Occupat Med, Lodz - Poland

^[13] Univ Iowa, Coll Publ Hlth, Iowa City, IA - USA

^[14] Russian Acad Med Sci, Canc Res Ctr, Moscow - Russia

^[15] New York Eye & Ear Infirm, New York, NY 10003 - USA

^[16] Natl Inst Environm Hlth, Budapest - Hungary

^[17] Univ Turin, Canc Epidemiol Unit, Dept Med Sci, Turin - Italy

^[18] Heidelberg Univ, Inst Publ Hlth, Heidelberg - Germany

^[19] Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC - USA

^[20] Univ Sao Paulo, Fac Med, Sao Paulo - Brazil

^[21] Penn State Coll Med, Hershey, PA - USA

^[22] Univ Sao Paulo, Fac Med, Cirurgia Cabeca & Pescoco LIM 28, Sao Paulo - Brazil

^[23] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 - USA

^[24] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 - USA

^[25] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 - USA

^[26] Univ Fed Pelotas, Pelotas - Brazil

^[27] Boston Univ, Sch Publ Hlth, Boston, MA - USA

^[28] Aichi Canc Ctr, Res Inst, Nagoya, Aichi 464 - Japan

^[29] Inst Publ Hlth, Bucharest - Romania

^[30] Univ Aberdeen, Sch Dent, Aberdeen - Scotland

^[31] M Skasodowska Curie Mem Canc Ctr, Warsaw - Poland

^[32] Inst Oncol, Dept Canc Epidemiol & Prevent, Warsaw - Poland

^[33] Univ Lausanne, Lausanne - Switzerland

^[34] CHU Vaudois, IUMSP, CH-1011 Lausanne - Switzerland

^[35] Washington State Univ, Coll Pharm, Spokane, WA - USA

^[36] Ist Ric Farmacol Mario Negri, IRCCS, Milan - Italy

^[37] Univ Milan, Dept Clin Sci & Community Hlth, Milan - Italy

^[38] Univ Athens, Sch Med, GR-11527 Athens - Greece

^[39] Fundacao Osvvaldo Cruz, Escola Nacl Saude Publ, Rio De Janeiro - Brazil

^[40] Canc Registry Norway, Oslo - Norway

^[41] Brown Univ, Dept Pathol & Lab Med, Providence, RI 02912 - USA

^[42] Charles Univ Prague, Fac Med 1, Prague - Czech Republic

^[43] WHO, Int Agcy Res Canc, Prevent & Implementat Grp, Lyon - France

^[44] Trinity Coll Sch Dent Sci, Dublin - Ireland

^[45] NYU, Sch Med, Div Epidemiol, New York, NY - USA

^[46] Int Agcy Res Canc, F-69372 Lyon - France

^[47] Inst Oncol & Radiobiol, Havana - Cuba

^[48] Reg Author Publ Hlth Banska Bystrica, Banska Bystrica - Slovakia

^[49] Hosp Clin Porto Alegre, Porto Alegre, RS - Brazil

^[50] Secretaria Estado Saude Sao Paulo, Hosp Heliopolis, Sao Paulo - Brazil

^[51] Int Prevent Res Inst, Lyon - France

^[52] Univ Glasgow, Sch Dent, Coll Med Vet & Life Sci, Glasgow, Lanark - Scotland

^[53] CIBER ESP, IDIBELL, ICO, Barcelona - Spain

^[54] Univ Padua, Padua - Italy

^[55] Univ Cattolica Sacro Cuore, Inst Otorhinolaryngol, Rome - Italy

^[56] Univ Cattolica Sacro Cuore, Inst Publ Hlth, Rome - Italy

^[57] BIPS, Leibniz Inst Prevent Res & Epidemiol, Bremen - Germany

^[58] Univ Bremen, Inst Stat, Fac Math & Comp Sci, D-28359 Bremen - Germany

^[59] IDIBELL, ICO, Barcelona - Spain

^[60] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY - USA

^[61] Univ Utah, Sch Med, Huntsnnan Canc Inst, Salt Lake City, UT - USA

^[62] Univ Utah, Sch Med, Dept Family & Prevent Med, Div Publ Hlth, Salt Lake City, UT 84112 - USA

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Epidemiology; v. 44, n. 1, p. 169-185, FEB 2015.
• Citações Web of Science: 49

Resumo

Background: Increasing incidence of head and neck cancer (HNC) in young adults has been reported. We aimed to compare the role of major risk factors and family history of cancer in HNC in young adults and older patients. Methods: We pooled data from 25 case-control studies and conducted separate analyses for adults <= 45 years old ('young adults', 2010 cases and 4042 controls) and > 45 years old ('older adults', 17 700 cases and 22 704 controls). Using logistic regression with studies treated as random effects, we estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Results: The young group of cases had a higher proportion of oral tongue cancer (16.0% in women; 11.0% in men) and unspecified oral cavity / oropharynx cancer (16.2%; 11.1%) and a lower proportion of larynx cancer (12.1%; 16.6%) than older adult cases. The proportions of never smokers or never drinkers among female cases were higher than among male cases in both age groups. Positive associations with HNC and duration or pack-years of smoking and drinking were similar across age groups. However, the attributable fractions (AFs) for smoking and drinking were lower in young when compared with older adults (AFs for smoking in young women, older women, young men and older men, respectively, =19.9% (95% CI = 9.8%, 27.9%), 48.9% (46.6%, 50.8%), 46.2% (38.5%, 52.5%), 64.3% (62.2%, 66.4%); AFs for drinking = 5.3% (-11.2%, 18.0%), 20.0% (14.5%, 25.0%), 21.5% (5.0%, 34.9%) and 50.4% (46.1%, 54.3%). A family history of early-onset cancer was associated with HNC risk in the young {[}OR = 2.27 (95% CI = 1.26, 4.10)], but not in the older adults {[}OR = 1.10 (0.91, 1.31)]. The attributable fraction for family history of early-onset cancer was 23.2% (8.60% to 31.4%) in young compared with 2.20% (-2 .41%, 5.80%) in older adults. Conclusions: Differences in HNC aetiology according to age group may exist. The lower AF of cigarette smoking and alcohol drinking in young adults may be due to the reduced length of exposure due to the lower age. Other characteristics, such as those that are inherited, may play a more important role in HNC in young adults compared with older adults. (AU)

• Processo FAPESP: 10/51168-0 - Fatores ambientais, clínicos, histopatológicos e moleculares associados ao desenvolvimento e ao prognóstico de carcinomas epidermoides de cabeça e pescoço
• Beneficiário: Eloiza Helena Tajara da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 04/12054-9 - Busca de marcadores de agressividade em tumores de cabeça e pescoço
• Beneficiário: Eloiza Helena Tajara da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 01/01768-2 - Estudo internacional de fatores ambientais, vírus e câncer de cavidade oral e de laringe
• Beneficiário: José Eluf Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular