Effects of exercise training on neurovascular control and skeletal myopathy in systolic heart failure

Autor(es)

Negrao, Carlos E. ^{[1, 2]} ; Middlekauff, Holly R. ^[3] ; Gomes-Santos, Igor L. ^[1] ; Antunes-Correa, Ligia M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Heart Inst InCor, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo - Brazil

^[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med Cardiol & Physiol, Los Angeles, CA 90095 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY; v. 308, n. 8, p. H792-H802, APR 15 2015.
• Citações Web of Science: 19

Resumo

Neurohormonal excitation and dyspnea are the hallmarks of heart failure (HF) and have long been associated with poor prognosis in HF patients. Sympathetic nerve activity (SNA) and ventilatory equivalent of carbon dioxide (VE/VO2) are elevated in moderate HF patients and increased even further in severe HF patients. The increase in SNA in HF patients is present regardless of age, sex, and etiology of systolic dysfunction. Neurohormonal activation is the major mediator of the peripheral vasoconstriction characteristic of HF patients. In addition, reduction in peripheral blood flow increases muscle inflammation, oxidative stress, and protein degradation, which is the essence of the skeletal myopathy and exercise intolerance in HF. Here we discuss the beneficial effects of exercise training on resting SNA in patients with systolic HF and its central and peripheral mechanisms of control. Furthermore, we discuss the exercise-mediated improvement in peripheral vasoconstriction in patients with HF. We will also focus on the effects of exercise training on ventilatory responses. Finally, we review the effects of exercise training on features of the skeletal myopathy in HF. In summary, exercise training plays an important role in HF, working synergistically with pharmacological therapies to ameliorate these abnormalities in clinical practice. (AU)

• Processo FAPESP: 10/50048-1 - Bases celulares e funcionais do exercício físico na doença cardiovascular
• Beneficiário: Carlos Eduardo Negrão
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/15651-7 - Efeitos do Treinamento Físico Aeróbio Associado ao Treinamento Muscular Inspiratório na Miopatia Esquelética em Pacientes com Insuficiência Cardíaca
• Beneficiário: Lígia de Moraes Antunes Corrêa
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/13690-8 - Papel do exercício físico na prevenção da cardiotoxicidade provocada pelo agente quimioterápico doxorrubicina
• Beneficiário: Igor Lucas Gomes dos Santos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado