Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effects of exercise training on neurovascular control and skeletal myopathy in systolic heart failure

Texto completo
Autor(es):
Negrao, Carlos E. [1, 2] ; Middlekauff, Holly R. [3] ; Gomes-Santos, Igor L. [1] ; Antunes-Correa, Ligia M. [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med, Heart Inst InCor, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo - Brazil
[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med Cardiol & Physiol, Los Angeles, CA 90095 - USA
Número total de Afiliações: 3
Tipo de documento: Artigo de Revisão
Fonte: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY; v. 308, n. 8, p. H792-H802, APR 15 2015.
Citações Web of Science: 19
Resumo

Neurohormonal excitation and dyspnea are the hallmarks of heart failure (HF) and have long been associated with poor prognosis in HF patients. Sympathetic nerve activity (SNA) and ventilatory equivalent of carbon dioxide (VE/VO2) are elevated in moderate HF patients and increased even further in severe HF patients. The increase in SNA in HF patients is present regardless of age, sex, and etiology of systolic dysfunction. Neurohormonal activation is the major mediator of the peripheral vasoconstriction characteristic of HF patients. In addition, reduction in peripheral blood flow increases muscle inflammation, oxidative stress, and protein degradation, which is the essence of the skeletal myopathy and exercise intolerance in HF. Here we discuss the beneficial effects of exercise training on resting SNA in patients with systolic HF and its central and peripheral mechanisms of control. Furthermore, we discuss the exercise-mediated improvement in peripheral vasoconstriction in patients with HF. We will also focus on the effects of exercise training on ventilatory responses. Finally, we review the effects of exercise training on features of the skeletal myopathy in HF. In summary, exercise training plays an important role in HF, working synergistically with pharmacological therapies to ameliorate these abnormalities in clinical practice. (AU)

Processo FAPESP: 14/13690-8 - Papel do exercício físico na prevenção da cardiotoxicidade provocada pelo agente quimioterápico doxorrubicina
Beneficiário:Igor Lucas Gomes dos Santos
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 13/15651-7 - Efeitos do treinamento físico aeróbio associado ao treinamento muscular inspiratório na miopatia esquelética em pacientes com insuficiência cardíaca
Beneficiário:Lígia de Moraes Antunes Corrêa
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 10/50048-1 - Bases celulares e funcionais do exercício físico na doença cardiovascular
Beneficiário:Carlos Eduardo Negrão
Linha de fomento: Auxílio à Pesquisa - Temático