Salivary, blood and plasma nitrite concentrations in periodontal patients and healthy individuals before and after periodontal treatment

Autor(es)

Meschiari, Cesar A. ^[1] ; Zuardi, Leonardo R. ^[2] ; Gomes, Valeria A. ^[3] ; Costa de Almeida, Glauce R. ^[2] ; Novaes, Jr., Arthur B. ^[4] ; Gerlach, Raquel F. ^[2] ; Marcaccini, Andrea M. ^[5]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Dept Morphol & Physiol & Basic Pathol, Sch Dent Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Dept Gynecol & Obstet, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Dept Oral Maxillofacial Surg & Traumatol & Period, Sch Dent Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil

^[5] Univ Ribeirao Preto UNAERP, Sch Dent, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinica Chimica Acta; v. 444, p. 293-296, APR 15 2015.
• Citações Web of Science: 4

Resumo

Background: To date, no study has employed ozone-based reductive chemiluminescence to compare nitrite concentration in the saliva of periodontal disease (PD) and healthy individuals or in the various blood compartments of the same individuals before and after periodontal treatment. We evaluated nitrite concentrations in whole, submandibular, and parotid saliva, as well as in whole blood, erythrocytes, and plasma of healthy volunteers and patients with chronic periodontitis. Methods: Data obtained for the PD and control groups were compared before and 3 months after periodontal therapy. Results: At baseline, stimulated whole saliva nitrite concentration was lower in PD patients (mean = 57.3 +/- 9.8 mu mol/L) as compared with healthy individuals (92.5 +/- 13.6 mu mol/L, P < 0.05). PD and periodontal treatment did not affect submandibular or parotid saliva nitrite concentrations. PD patients presented higher baseline whole blood nitrite concentration (238.4 +/- 45.7 mu mol/L) as compared with values recorded 3 months after therapy (141.3 +/- 20.1 nmol/L, P < 0.05). PD patients' erythrocytes exhibited higher baseline nitrite concentration (573.1 +/- 97.8 nmol/L) as compared with three months after therapy (298.7 +/- 52.1 nmol/L, P < 0.05). Again, PD and PD treatment did not impact plasma nitrite concentration. Conclusions: PD patients had lower nitrite concentration in whole saliva, and this situation remained unchanged after periodontal treatment. Nevertheless, erythrocytes and whole blood nitrite levels diminished after periodontal treatment. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 05/60527-6 - Perfil das metaloproteinases da matriz (MMPs) e inibidores teciduais das MMPs (TIMPs) no plasma, no fluído gengival e na saliva e sua correlação com marcadores plasmáticos de inflamação crônica em indivíduos com Doença Periodontal Crônica e indivíduos com saúde periodontal
• Beneficiário: Raquel Fernanda Gerlach
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 05/60526-0 - Correlação entre a metaloproteinase da matriz-9 (MMP-9) e marcadores inflamatórios plasmáticos em indivíduos com doença periodontal crônica antes e após o tratamento
• Beneficiário: Andréa Marcia Marcaccini
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado