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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Multiple Phosphatases Regulate Carbon Source-Dependent Germination and Primary Metabolism in Aspergillus nidulans

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Autor(es):
de Assis, Leandro Jose [1] ; Annick Ries, Laure Nicolas [1] ; Savoldi, Marcela [1] ; Dinamarco, Taisa Magnani [2] ; Goldman, Gustavo Henrique [1, 3] ; Brown, Neil Andrew [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Sao Paulo - Brazil
[3] CTBE CNPEM, Lab Nacl Ciencia & Tecnol Bioetanol, BR-13083970 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: G3-GENES, GENOMES, GENETICS; v. 5, n. 5, p. 857-872, MAY 1 2015.
Citações Web of Science: 6
Assunto(s):Germinação   Monoester fosfórico hidrolases   Ciclo celular   Saccharomyces cerevisiae   Neurospora crassa
Resumo

Aspergillus nidulans is an important mold and a model system for the study of fungal cell biology. In addition, invasive A. nidulans pulmonary infections are common in humans with chronic granulomatous disease. The morphological and biochemical transition from dormant conidia into active, growing, filamentous hyphae requires the coordination of numerous biosynthetic, developmental, and metabolic processes. The present study exhibited the diversity of roles performed by seven phosphatases in regulating cell cycle, development, and metabolism in response to glucose and alternative carbon sources. The identified phosphatases highlighted the importance of several signaling pathways regulating filamentous growth, the action of the pyruvate dehydrogenase complex as a metabolic switch controlling carbon usage, and the identification of the key function performed by the alpha-ketoglutarate dehydrogenase during germination. These novel insights into the fundamental roles of numerous phosphatases in germination and carbon sensing have provided new avenues of research into the identification of inhibitors of fungal germination, with implications for the food, feed, and pharmaceutical industries. (AU)

Processo FAPESP: 14/00789-6 - Caracterização funcional de fosfatases de Aspergillus nidulans envolvidas no metabolismo da glicose
Beneficiário:Leandro Jose de Assis
Linha de fomento: Bolsas no Brasil - Pós-Doutorado