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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Multiple Phosphatases Regulate Carbon Source-Dependent Germination and Primary Metabolism in Aspergillus nidulans

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Author(s):
de Assis, Leandro Jose [1] ; Annick Ries, Laure Nicolas [1] ; Savoldi, Marcela [1] ; Dinamarco, Taisa Magnani [2] ; Goldman, Gustavo Henrique [1, 3] ; Brown, Neil Andrew [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Sao Paulo - Brazil
[3] CTBE CNPEM, Lab Nacl Ciencia & Tecnol Bioetanol, BR-13083970 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: G3-GENES, GENOMES, GENETICS; v. 5, n. 5, p. 857-872, MAY 1 2015.
Web of Science Citations: 6
Abstract

Aspergillus nidulans is an important mold and a model system for the study of fungal cell biology. In addition, invasive A. nidulans pulmonary infections are common in humans with chronic granulomatous disease. The morphological and biochemical transition from dormant conidia into active, growing, filamentous hyphae requires the coordination of numerous biosynthetic, developmental, and metabolic processes. The present study exhibited the diversity of roles performed by seven phosphatases in regulating cell cycle, development, and metabolism in response to glucose and alternative carbon sources. The identified phosphatases highlighted the importance of several signaling pathways regulating filamentous growth, the action of the pyruvate dehydrogenase complex as a metabolic switch controlling carbon usage, and the identification of the key function performed by the alpha-ketoglutarate dehydrogenase during germination. These novel insights into the fundamental roles of numerous phosphatases in germination and carbon sensing have provided new avenues of research into the identification of inhibitors of fungal germination, with implications for the food, feed, and pharmaceutical industries. (AU)

FAPESP's process: 14/00789-6 - Functional characterization of Aspergillus nidulans phosphatases involved on glucose metabolism
Grantee:Leandro Jose de Assis
Support Opportunities: Scholarships in Brazil - Post-Doctoral