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Functional characterization of Aspergillus nidulans phosphatases involved on glucose metabolism

Grant number: 14/00789-6
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): February 01, 2015
Effective date (End): December 21, 2019
Field of knowledge:Biological Sciences - Biochemistry - Biochemistry of Microorganisms
Principal Investigator:Gustavo Henrique Goldman
Grantee:Leandro Jose de Assis
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:16/07870-9 - The influence of mitogen activated protein kinases (MAPK) on the expression of genetic determinants important for Aspergillus fumigatus virulence, AP.TEM
Associated scholarship(s):17/23624-0 - Mitogen-activated protein kinases (MAPK) interactome dynamics regulating carbon catabolite repression in Aspergillus nidulans, BE.EP.PD   16/03900-0 - Identification of protein interactions involved in the regulation of carbon catabolite repression in Aspergillus nidulans, BE.EP.PD

Abstract

This work will understand the study of the use of different carbon sources by fungus Aspergillus nidulans, in particular the cellular signalling for to use glucose. For the accomplishment of this work will be used a library of the strains Aspergillus nidulans with deletions in different phosphatase genes. The phosphatases are enzymes that hydrolyze groupings phosphate of diverse promoters and genic repressors, being, therefore, directly on to the regulation of factors responsible for the use of diverse carbon sources. The main aim of this work will be to understand the possible mechanisms of regulation of modulators of carbon catabolic repression and to study the possible enzyme involved in the regulation of the carbohydrates metabolism.

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Scientific publications (13)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE ASSIS, LEANDRO JOSE; SILVA, LILIAN PEREIRA; LIU, LI; SCHMITT, KERSTIN; VALERIUS, OLIVER; BRAUS, GERHARD H.; ANNICK RIES, LAURE NICOLAS; GOLDMAN, GUSTAVO HENRIQUE. The High Osmolarity Glycerol Mitogen-Activated Protein Kinase regulates glucose catabolite repression in filamentous fungi. PLOS GENETICS, v. 16, n. 8, . (14/00789-6, 16/07870-9, 17/23624-0)
MANFIOLLI, ADRIANA OLIVEIRA; MATTOS, ELICIANE CEVOLANI; DE ASSIS, LEANDRO JOSE; SILVA, LILIAN PEREIRA; ULAS, MEVLUT; BROWN, NEIL ANDREW; SILVA-ROCHA, RAFAEL; BAYRAM, OZGUR; GOLDMAN, GUSTAVO H.. Aspergillus fumigatus High Osmolarity Glycerol Mitogen Activated Protein Kinases SakA and MpkC Physically Interact During Osmotic and Cell Wall Stresses. FRONTIERS IN MICROBIOLOGY, v. 10, . (16/07870-9, 17/19288-5, 14/00789-6)
DE OLIVEIRA BRUDER NASCIMENTO, ARIANE CRISTINA MENDES; DOS REIS, THAILA FERNANDA; DE CASTRO, PATRICIA ALVES; HORI, JULIANA I.; PEDRO BOM, VINICIUS LEITE; DE ASSIS, LEANDRO JOSE; ZAMBELLI RAMALHO, LEANDRA NAIRA; ROCHA, MARINA CAMPOS; MALAVAZI, IRAN; BROWN, NEIL ANDREW; et al. Mitogen activated protein kinases SakA(HOG1) and MpkC collaborate for Aspergillus fumigatus virulence. Molecular Microbiology, v. 100, n. 5, p. 841-859, . (14/00789-6)
DE ASSIS, LEANDRO JOSE; RIES, LAURE NICOLAS ANNICK; SAVOLDI, MARCELA; DOS REIS, THAILA FERNANDA; BROWN, NEIL ANDREW; GOLDMAN, GUSTAVO HENRIQUE. Aspergillus nidulans protein kinase A plays an important role in cellulase production. BIOTECHNOLOGY FOR BIOFUELS, v. 8, . (14/00789-6)
DE ASSIS, LEANDRO JOSE; ULAS, MEVLUT; ANNICK RIES, LAURE NICOLAS; EL RAMLI, NADIA ALI MOHAMED; SARIKAYA-BAYRAM, OZLEM; BRAUS, GERHARD H.; BAYRAM, OZGUR; GOLDMAN, GUSTAVO HENRIQUE. Regulation of Aspergillus nidulans CreA-Mediated Catabolite Repression by the F-Box Proteins Fbx23 and Fbx47. MBIO, v. 9, n. 3, p. 19-pg., . (14/00789-6, 16/07870-9, 16/03900-0)
DOS REIS, THAILA FERNANDA; NITSCHE, BENJAMIN M.; ALMEIDA DE LIMA, POLLYNE BORBOREMA; DE ASSIS, LEANDRO JOSE; MELLADO, LAURA; HARRIS, STEVEN D.; MEYER, VERA; CORREA DOS SANTOS, RENATO A.; RIANO-PACHON, DIEGO M.; ANNICK RIES, LAURE NICOLAS; et al. The low affinity glucose transporter HxtB is also involved in glucose signalling and metabolism in Aspergillus nidulans. SCIENTIFIC REPORTS, v. 7, . (14/00789-6)
DE ASSIS, LEANDRO JOSE; SILVA, LILIAN PEREIRA; BAYRAM, OZGUR; DOWLING, PAUL; KNIEMEYER, OLAF; KRUEGER, THOMAS; BRAKHAGE, AXEL A.; CHEN, YINGYING; DONG, LIGUO; TAN, KAELING; et al. Carbon Catabolite Repression in Filamentous Fungi Is Regulated by Phosphorylation of the Transcription Factor CreA. MBIO, v. 12, n. 1, . (16/03900-0, 16/07870-9, 14/00789-6, 17/14159-2)
DE ASSIS, LEANDRO JOSE; ULAS, MEVLUT; ANNICK RIES, LAURE NICOLAS; EL RAMLI, NADIA ALI MOHAMED; SARIKAYA-BAYRAM, OZLEM; BRAUS, GERHARD H.; BAYRAM, OZGUR; GOLDMAN, GUSTAVO HENRIQUE. Regulation of Aspergillus nidulans CreA-Mediated Catabolite Repression by the F-Box Proteins Fbx23 and Fbx47. MBIO, v. 9, n. 3, . (16/03900-0, 16/07870-9, 14/00789-6)
ANNICK RIES, LAURE NICOLAS; DE ASSIS, LEANDRO JOSE; SANTOS RODRIGUES, FERNANDO JOSE; CALDANA, CAMILA; ROCHA, MARINA CAMPOS; MALAVAZI, IRAN; BAYRAM, OZGUR; GOLDMAN, GUSTAVO H.. The Aspergillus nidulans Pyruvate Dehydrogenase Kinases Are Essential To Integrate Carbon Source Metabolism. G3-GENES, GENOMES, GENETICS, v. 8, n. 7, p. 2445-2463, . (16/07870-9, 14/00789-6)
MANFIOLLI, ADRIANA OLIVEIRA; SIQUEIRA, FILIPE SILVA; DOS REIS, THAILA FERNANDA; VAN DIJCK, PATRICK; SCHREVENS, SANNE; HOEFGEN, SANDRA; FOEGE, MARTIN; STRASSBURGER, MARIA; DE ASSIS, LEANDRO JOSE; HEINEKAMP, THORSTEN; et al. Mitogen-Activated Protein Kinase Cross-Talk Interaction Modulates the Production of Melanins in Aspergillus fumigatus. MBIO, v. 10, n. 2, . (14/24951-7, 14/00789-6, 16/07870-9)
DE ASSIS, LEANDRO JOSE; ANNICK RIES, LAURE NICOLAS; SAVOLDI, MARCELA; DINAMARCO, TAISA MAGNANI; GOLDMAN, GUSTAVO HENRIQUE; BROWN, NEIL ANDREW. Multiple Phosphatases Regulate Carbon Source-Dependent Germination and Primary Metabolism in Aspergillus nidulans. G3-GENES, GENOMES, GENETICS, v. 5, n. 5, p. 857-872, . (14/00789-6)
RIES, LAURE N. A.; PARDESHI, LAKHANSING; DONG, ZHICLIANG; TAN, KAELING; STEENWYK, JACOB L.; COLABARDINI, ANA CRISTINA; FERREIRA FILHO, JAIRE A.; DE CASTRO, PATRICIA A.; SILVA, LILIAN P.; PREITE, NYCOLAS W.; et al. The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence. PLOS PATHOGENS, v. 16, n. 7, . (17/14159-2, 17/21983-3, 18/25217-6, 17/07536-4, 17/01188-4, 13/50954-0, 14/00789-6, 13/07937-8, 16/07870-9, 19/09278-8, 16/03322-7)
SILVA, LILIAN PEREIRA; FRAWLEY, DEAN; DE ASSIS, LEANDRO JOSE; TIERNEY, CIARA; FLEMING, ALASTAIR B.; BAYRAM, OZGUR; GOLDMAN, GUSTAVO HENRIQUE. Putative Membrane Receptors Contribute to Activation and Efficient Signaling of Mitogen-Activated Protein Kinase Cascades during Adaptation of Aspergillus fumigatus to Different Stressors and Carbon Sources. MSPHERE, v. 5, n. 5, . (16/07870-9, 14/00789-6, 16/21392-2)

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