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The influence of mitogen activated protein kinases (MAPK) on the expression of genetic determinants important for Aspergillus fumigatus virulence

Grant number: 16/07870-9
Support type:Research Projects - Thematic Grants
Duration: July 01, 2017 - June 30, 2022
Field of knowledge:Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
Principal researcher:Gustavo Henrique Goldman
Grantee:Gustavo Henrique Goldman
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Principal researchers:Iran Malavazi
Assoc. researchers: Agostinho Albérico Rodrigues de Carvalho
Associated grant(s):19/23231-4 - Characterizing the genomic and phenotypic diversity of clinical isolates from human fungal pathogens in the Aspergillus nidulans species complex, AP.R SPRINT
18/22040-8 - Fungal receptor-mediated glucose sensing regulates light-dependent development and toxin production, AP.R SPRINT
Associated scholarship(s):20/10536-9 - Organization and integration of large scale data to study the dynamics of expression of MAP kinases of the fungus Aspergillus fumigatus in diverse genetic and environmental conditions, BP.TT
19/10727-1 - Molecular characterization of a receptor coupled to a g protein (GPCR) of Aspergillus fumigatus, BP.MS
18/25217-6 - Organization and integration of large scale data to study the dynamics of expression of map kinases of the fungus Aspergillus fumigatus in diverse genetic and environmental conditions, BP.TT
+ associated scholarships 18/00715-3 - Molecular characterization of Aspergillus fumigatus transcription factors involved in calcium metabolism., BP.PD
17/19288-5 - Characterization of MAPKs dependent-phosphoproteomes of Aspergillus fumigatus under stress conditions, BP.PD
18/00315-5 - The influence of mitogen activated protein kinases (MAPK) on the expression of genetic determinants important for Aspergillus fumigatus virulence, BP.PD
16/12948-7 - The role of mitogen-activated protein kinase (MPKA) MpkA in regulating gliotoxin production in Aspergillus fumigatus., BP.PD
14/24951-7 - Identification of targets regulated by Aspergillus fumigatus phosphatase PhzA, BP.PD
14/00789-6 - Functional characterization of Aspergillus nidulans phosphatases involved on glucose metabolism, BP.PD - associated scholarships

Abstract

MAP kinases and phosphatases are the main signaling pathways of tolerance to different kinds of stresses in eukaryotes. The multifactorial nature of A. fumigatus virulence and pathogenicity program in the mammalian host places the response to different kinds of stresses as one of the most important responses in the process of establishment of this organism as a pathogen. These signaling pathways are important for the cell wall biosynthesis and remodeling, responses to oxidative stress and antifungal drugs, biofilm formation and adhesion, and possibly other essential features not yet investigated such as, blood dissemination from the pulmonary epithelium and strategies of immunological evasion. The understanding of the metabolic nets that are coordinated by MAP kinases will provide an opportunity for the construction of the signaling pathways that are important for stress tolerance and the establishment of the A. fumigatus virulence and pathogenicity program in mammals. Thus, the main objectives of this project are: (i) the identification of specific transcription factors that are activated by different kinds of stress and that are dependent on MAP kinases; (ii) the identification of proteins that interact physically with the MAP kinases when A. fumigatus is exposed to different kinds of stresses; (iii) the investigation of a possible "crosstalk" among the different A. fumigatus MAP kinases during different kinds of stresses; (iv) the molecular characterization of MpkB and the verification if this MAP kinase is important for A. fumigatus virulence, and (v) the characterization of the interaction between the A. fumigatus mutants generated in this study and the immunosupressed and imunocompetent murine hosts. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Investigan los hábitos sexuales de los hongos para combatir a las especies nocivas 
Descubren un hongo híbrido implicado en infecciones pulmonares 
Pesquisador da USP de Ribeirão Preto recebe prêmio da American Society of Microbiology 
Researchers discover hybrid fungus involved in lung infections 
Research group studies the sexual habits of fungi in search of strategies to combat harmful species 
Grupo estuda hábitos sexuais de fungos em busca de estratégias para combater espécies nocivas  
Substance in fungal spores helps species protect itself from competitors and infect humans  
Al rescate de una sustancia de las esporas de un hongo nociva para sus competidores y para los humanos  
Articles published in other media outlets (106 total):
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G1: Descoberto fungo ‘de plantas’ capaz de gerar infecções pulmonares em humanos (30/Jun/2020)
UOL: Pesquisadores descobrem fungo híbrido envolvido em infecções pulmonares (18/Jun/2020)
Health Medicine Network (EUA): Researchers discover hybrid fungus involved in lung infections (28/Jul/2020)
Blog Damage Mold: Researchers discover hybrid fungus involved in lung infections (25/Jul/2020)
Lotgain: Pesquisadores descobrem fungos mistos ligados a infecções pulmonares (23/Jul/2020)
Scientific Inquirer (EUA): New form of fungus discovered in hospital lung infection (21/Jul/2020)
Xsjk (China): Pesquisadores descobrem fungo híbrido ligado a infecções pulmonares (21/Jul/2020)
Phys.Org (Reino Unido): Researchers discover hybrid fungus involved in lung infections (20/Jul/2020)
Brightsurf: Researchers discover hybrid fungus involved in lung infections (20/Jul/2020)
Mindzilla (Reino Unido): Researchers discover hybrid fungus involved in lung infections (20/Jul/2020)
Innovations Report (Alemanha): Researchers Discover Hybrid Fungus Involved In Lung Infections (20/Jul/2020)
Healthwire (Índia): New Species Of Fungus Discovered For The First Time In Hospital Environment; May Involved In Lung Infections (20/Jul/2020)
BioTech.WS: Researchers discover hybrid fungus involved in lung infections (20/Jul/2020)
Healthcare Hygiene Magazine (EUA): Researchers discover hybrid fungus involved in lung infections (20/Jul/2020)
Corona Stocks (Canadá): Researchers discover hybrid fungus involved in lung infections (20/Jul/2020)
Knowledia (França): Hybrid fungus involved in lung infections discovered (20/Jul/2020)
Occupy Independents (EUA): Researchers Discover Hybrid Fungus Involved In Lung Infections (20/Jul/2020)
Burada Biliyorum (Turquia): Researchers discover hybrid fungus involved in lung infections (20/Jul/2020)
Thailand Medical News (Tailândia): Breaking! COVID-19 News: Scientists Discover Drug-Resistant Hybrid Fungus Aspergillus Latus Involved In Lung Infections Of Certain COVID-19 Patients (20/Jul/2020)
Today News Post (EUA): Researchers discover hybrid fungus involved in lung infections (20/Jul/2020)
RunForen: Researchers discover hybrid fungus involved in lung infections (20/Jul/2020)
New Zealand Online News (Nova Zelândia): Covid patients dying of unique fungus, researchers begin probe (20/Jul/2020)
Erode District (Índia): Hybrid fungus involved in lung infections discover (20/Jul/2020)
Clinical Services Journal online (Reino Unido): Aspergillus Latus Found In A Hospital Environment For The First Time (20/Jul/2020)
News Medical (Austrália): Hybrid fungus involved in lung infections discovered (19/Jul/2020)
MSN (Índia): Role of Fungi in COVID-19: Researchers Begin Probe as Coronavirus Patients Die of Unique Fungus (19/Jul/2020)
LabRoots (EUA): A Hybrid Fungus Is Linked to Lung Infections (19/Jul/2020)
Web India 123 (Índia): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
Sify (Índia): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
Daijiworld (Índia): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
Newkerala.com (Índia): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
CanIndia (Índia): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
Seattle Indian (EUA): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
Daily Hunt (Índia): Researchers to probe role of a unique fungus in COVID-19 deaths (19/Jul/2020)
India.com: Role of Fungi in COVID-19: Researchers Begin Probe as Coronavirus Patients Die of Unique Fungus (19/Jul/2020)
News Dog Today (Índia): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
NP News24 (Índia): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
Newsd (Índia): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
The Tribune (Chandigarh, Índia) online: Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
Bhaskar Live (Índia): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
Lokmat.com: Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
DT Next (Índia): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
tfipost.com (Índia): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
OrlandoIndian.com (EUA): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
The Weather Channel (EUA): COVID-19 Patients Dying Due to Unique Fungal Infection; Researchers Begin Investigation (19/Jul/2020)
Los Angeles Indian Community (EUA): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
The Samikhsya (Índia): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
Bio1000 (China): Pesquisadores descobrem fungo híbrido ligado a infecções pulmonares (19/Jul/2020)
Free Press Journal (Índia) online: Researchers to probe role of a unique fungus in COVID-19 deaths (19/Jul/2020)
New York Indian Community (EUA): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
Telugu Political Bureau: Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
Fresherslive (Índia): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
Andhram.com (Índia): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
IND News (Índia): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
People's Post India (Índia): Covid patients dying of unique fungus (19/Jul/2020)
Hello English (Índia): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
eNews Time (Índia): Hybrid fungus in lung infections found: Role of fungi in Covid-19 under scanner (19/Jul/2020)
TeluguIN.com: Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
1947.com: Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
NirogStreet (Índia): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
India Updates (Índia): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
Dineshrewale.com: Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
TwistArticle (Índia): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
SaveDelete (Índia): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
Salty Sardonic - Health And Medical (Índia): Hybrid fungus involved in lung infections discover (19/Jul/2020)
Secret of Weight (EUA): Hybrid fungus involved in lung infections discovered (19/Jul/2020)
Health Wellness Journal (EUA): Hybrid fungus involved in lung infections discovered (19/Jul/2020)
JacksonvilleIndian.com (EUA): Covid patients dying of unique fungus, researchers begin probe (19/Jul/2020)
The Weather Channel (Índia): COVID-19 Patients Dying Due to Unique Fungal Infection; Researchers Begin Investigation (19/Jul/2020)
The Medical News Inc - Latest Medical News On The Go: Hybrid fungus involved in lung infections discovered (19/Jul/2020)
Bioengineer (Reino Unido): Researchers discover hybrid fungus involved in lung infections (17/Jul/2020)
Science Codex: Researchers discover hybrid fungus involved in lung infections (17/Jul/2020)
Scienmag Science Magazine (Reino Unido): Researchers discover hybrid fungus involved in lung infections (17/Jul/2020)
Agenparl (Itália): Researchers discover hybrid fungus involved in lung infections (17/Jul/2020)
7thSpace: Researchers discover hybrid fungus involved in lung infections (17/Jul/2020)
Webinfoservices.in: Researchers discover hybrid fungus involved in lung infections (17/Jul/2020)
Boost my Wellness (Índia): Researchers discover hybrid fungus involved in lung infections (17/Jul/2020)
Indiaroba Web: Descoberto fungo ‘de plantas’ capaz de gerar infecções pulmonares em humanos (30/Jun/2020)
Biblioteca FMUSP: Fungo híbrido é encontrado em infecções pulmonares (24/Jun/2020)
Região Noroeste : Pesquisadores descobrem fungo híbrido em infecções pulmonares (19/Jun/2020)
Plantão News (MT): Pesquisadores descobrem fungo híbrido envolvido em infecções pulmonares (19/Jun/2020)
Espaço Ecológico no Ar: Pesquisadores descobrem fungo híbrido envolvido em infecções pulmonares (19/Jun/2020)
LabNetwork: Pesquisadores descobrem fungo híbrido envolvido em infecções pulmonares (19/Jun/2020)
GR Notícias: Pesquisadores descobrem fungo híbrido envolvido em infecções pulmonares (19/Jun/2020)
Beto Ribeiro Repórter: Fapesp: Pesquisadores descobrem fungo híbrido envolvido em infecções pulmonares (19/Jun/2020)
Duna Press : São Paulo: Pesquisadores descobrem fungo híbrido envolvido em infecções pulmonares (19/Jun/2020)
Mundo e Meio: Pesquisadores descobrem fungo híbrido envolvido em infecções pulmonares (19/Jun/2020)
Portal do Governo do Estado de São Paulo: Fapesp: Pesquisadores descobrem fungo híbrido envolvido em infecções pulmonares (18/Jun/2020)
Diário da Saúde: Fungo híbrido envolvido em infecções pulmonares é descoberto em hospitais (18/Jun/2020)
Revista Amazônia: Pesquisadores descobrem fungo híbrido envolvido em infecções pulmonares (18/Jun/2020)
Jornal da Ciência online: Pesquisadores descobrem fungo híbrido envolvido em infecções pulmonares (18/Jun/2020)
Folha Nobre: Pesquisadores descobrem fungo híbrido envolvido em infecções pulmonares (18/Jun/2020)
Notícias de Campinas: Pesquisadores descobrem fungo híbrido envolvido em infecções pulmonares (18/Jun/2020)
Mix Vale: Pesquisadores descobrem fungo híbrido envolvido em infecções pulmonares (18/Jun/2020)
Portal da Enfermagem: Pesquisadores descobrem fungo híbrido envolvido em infecções pulmonares (18/Jun/2020)
Central das Notícias: Pesquisadores descobrem fungo híbrido envolvido em infecções pulmonares (18/Jun/2020)
Coluna Supinando: Estudo descobre fungo híbrido envolvido em infecções pulmonares (18/Jun/2020)
Mirage News (Austrália): New discovery shows infection of lungs can be caused by hybrid fungi (05/Jun/2020)
Vanderbilt University (EUA): New discovery shows infection of the lungs can be caused by hybrid fungi (04/Jun/2020)
Plantão News (MT): Grupo estuda hábitos sexuais de fungos em busca de estratégias para combater espécies nocivas (05/Mar/2020)
Espaço Ecológico no Ar: Grupo estuda hábitos sexuais de fungos em busca de estratégias para combater espécies nocivas (05/Mar/2020)
Revista Analytica online: Como estratégia no combate a espécies nocivas, grupo estuda hábitos sexuais de fungos (05/Mar/2020)
Mundo e Meio: Grupo estuda hábitos sexuais de fungos em busca de estratégias para combater espécies nocivas (05/Mar/2020)
Revista Cultivar Máquinas online: Grupo estuda hábitos sexuais de fungos para combater espécies nocivas (04/Mar/2020)
LabNetwork: Grupo estuda hábitos sexuais de fungos para combater espécies nocivas (04/Mar/2020)
Jornal Imprensa Regional: Pesquisadores descobrem fungo híbrido envolvido em infecções pulmonares (18/Jun/2020)

Scientific publications (27)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
JOHNS, LOUISE E.; GOLDMAN, GUSTAVO H.; RIES, LAURE N. A.; BROWN, NEIL A. Nutrient sensing and acquisition in fungi: mechanisms promoting pathogenesis in plant and human hosts. FUNGAL BIOLOGY REVIEWS, v. 36, p. 1-14, JUN 2021. Web of Science Citations: 0.
ROCHA, MARINA CAMPOS; MINARI, KARINE; FABRI, JOAO HENRIQUE TADINI MARILHANO; KERKAERT, JOSHUA D.; GAVA, LISANDRA MARQUES; DA CUNHA, ANDERSON FERREIRA; CRAMER, ROBERT A.; BORGES, JULIO CESAR; MALAVAZI, IRAN. Aspergillus fumigatusHsp90 interacts with the main components of the cell wall integrity pathway and cooperates in heat shock and cell wall stress adaptation. Cellular Microbiology, v. 23, n. 2 FEB 2021. Web of Science Citations: 1.
DE ASSIS, LEANDRO JOSE; SILVA, LILIAN PEREIRA; BAYRAM, OZGUR; DOWLING, PAUL; KNIEMEYER, OLAF; KRUEGER, THOMAS; BRAKHAGE, AXEL A.; CHEN, YINGYING; DONG, LIGUO; TAN, KAELING; WONG, KOON HO; RIES, LAURE N. A.; GOLDMAN, GUSTAVO H. Carbon Catabolite Repression in Filamentous Fungi Is Regulated by Phosphorylation of the Transcription Factor CreA. MBIO, v. 12, n. 1 JAN-FEB 2021. Web of Science Citations: 0.
DE CASTRO, PATRICIA ALVES; VALERO, CLARA; CHIARATTO, JESSICA; COLABARDINI, ANA CRISTINA; PARDESHI, LAKHANSING; SILVA, LILIAN PEREIRA; ALMEIDA, FAUSTO; ROCHA, MARINA CAMPOS; SILVA, ROBERTO NASCIMENTO; MALAVAZI, IRAN; DU, WENYUE; DYER, PAUL S.; BROCK, MATTHIAS; LOURES, FLAVIO VIEIRA; WONG, KOON HO; GOLDMAN, GUSTAVO H. Novel Biological Functions of the NsdC Transcription Factor in Aspergillus fumigatus. MBIO, v. 12, n. 1 JAN-FEB 2021. Web of Science Citations: 0.
FABRI, JOAO HENRIQUE TADINI MARILHANO; DE SA, NIVEA PEREIRA; MALAVAZI, IRAN; DEL POETA, MAURIZIO. The dynamics and role of sphingolipids in eukaryotic organisms upon thermal adaptation. PROGRESS IN LIPID RESEARCH, v. 80, NOV 2020. Web of Science Citations: 0.
STEENWYK, JACOB L.; MEAD, MATTHEW E.; KNOWLES, SONJA L.; RAJA, HUZEFA A.; ROBERTS, CHRISTOPHER D.; BADER, OLIVER; HOUBRAKEN, JOS; GOLDMAN, GUSTAVO H.; OBERLIES, NICHOLAS H.; ROKAS, ANTONIS. Variation Among Biosynthetic Gene Clusters, Secondary Metabolite Profiles, and Cards of Virulence AcrossAspergillusSpecies. Genetics, v. 216, n. 2, p. 481-497, OCT 2020. Web of Science Citations: 0.
CORREA DOS SANTOS, RENATO AUGUSTO; RIVERO-MENENDEZ, OLGA; STEENWYK, JACOB L.; MEAD, MATTHEW E.; GOLDMAN, GUSTAVO HENRIQUE; ALASTRUEY-IZQUIERDO, ANA; ROKAS, ANTONIS. Draft Genome Sequences of Four Aspergillus Section Fumigati Clinical Strains. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 9, n. 40 OCT 2020. Web of Science Citations: 0.
DA COSTA FILHO, AILTON PEREIRA; PEREIRA BRANCINI, GUILHERME THOMAZ; DE CASTRO, PATRICIA ALVES; VALERO, CLARA; FERREIRA FILHO, JAIRE ALVES; SILVA, LILIAN PEREIRA; ROCHA, MARINA CAMPOS; MALAVAZI, IRAN; DE MORAES PONTES, JOAO GUILHERME; FILL, TAICIA; SILVA, ROBERTO NASCIMENTO; ALMEIDA, FAUSTO; STEENWYK, JACOB L.; ROKAS, ANTONIS; DOS REIS, THAILA F.; RIES, LAURE N. A.; GOLDMAN, GUSTAVO H. Aspergillus fumigatus G-Protein Coupled Receptors GprM and GprJ Are Important for the Regulation of the Cell Wall Integrity Pathway, Secondary Metabolite Production, and Virulence. MBIO, v. 11, n. 5 SEP-OCT 2020. Web of Science Citations: 1.
SILVA, LILIAN PEREIRA; FRAWLEY, DEAN; DE ASSIS, LEANDRO JOSE; TIERNEY, CIARA; FLEMING, ALASTAIR B.; BAYRAM, OZGUR; GOLDMAN, GUSTAVO HENRIQUE. Putative Membrane Receptors Contribute to Activation and Efficient Signaling of Mitogen-Activated Protein Kinase Cascades during Adaptation of Aspergillus fumigatus to Different Stressors and Carbon Sources. MSPHERE, v. 5, n. 5 SEP-OCT 2020. Web of Science Citations: 0.
DE ASSIS, LEANDRO JOSE; SILVA, LILIAN PEREIRA; LIU, LI; SCHMITT, KERSTIN; VALERIUS, OLIVER; BRAUS, GERHARD H.; ANNICK RIES, LAURE NICOLAS; GOLDMAN, GUSTAVO HENRIQUE. The High Osmolarity Glycerol Mitogen-Activated Protein Kinase regulates glucose catabolite repression in filamentous fungi. PLOS GENETICS, v. 16, n. 8 AUG 2020. Web of Science Citations: 0.
STEENWYK, JACOB L.; LIND, ABIGAIL L.; RIES, LAURE N. A.; DOS REIS, THAILA F.; SILVA, LILIAN P.; ALMEIDA, FAUSTO; BASTOS, RAFAEL W.; FRAGA DA SILVA, THAIS FERNANDA DE CAMPOS; BONATO, VANIA L. D.; PESSONI, ANDRE MOREIRA; RODRIGUES, FERNANDO; RAJA, HUZEFA A.; KNOWLES, SONJA L.; OBERLIES, NICHOLAS H.; LAGROU, KATRIEN; GOLDMAN, GUSTAVO H.; ROKAS, ANTONIS. Pathogenic Allodiploid Hybrids of Aspergillus Fungi. Current Biology, v. 30, n. 13, p. 2495+, JUL 6 2020. Web of Science Citations: 0.
RIES, LAURE N. A.; PARDESHI, LAKHANSING; DONG, ZHICLIANG; TAN, KAELING; STEENWYK, JACOB L.; COLABARDINI, ANA CRISTINA; FERREIRA FILHO, JAIRE A.; DE CASTRO, PATRICIA A.; SILVA, LILIAN P.; PREITE, NYCOLAS W.; ALMEIDA, FAUSTO; DE ASSIS, LEANDRO J.; DOS SANTOS, RENATO A. C.; BOWYER, PAUL; BROMLEY, MICHAEL; OWENS, REBECCA A.; DOYLE, SEAN; DEMASI, MARILENE; HERNANDEZ, DIEGO C. R.; NETTO, LUIS EDUARDO S.; PUPO, MONICA T.; ROKAS, ANTONIS; LOURES, V, FLAVIO; WONG, KOON H.; GOLDMAN, GUSTAVO H. The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence. PLOS PATHOGENS, v. 16, n. 7 JUL 2020. Web of Science Citations: 0.
DOS SANTOS, RENATO A. C.; STEENWYK, JACOB L.; RIVERO-MENENDEZ, OLGA; MEAD, MATTHEW E.; SILVA, LILIAN P.; BASTOS, RAFAEL W.; ALASTRUEY-LZQUIERDO, ANA; GOLDMAN, GUSTAVO H.; ROKAS, ANTONIS. Genomic and Phenotypic Heterogeneity of Clinical Isolates of the Human Pathogens Aspergillus fumigatus, Aspergillus lentulus, and Aspergillus fumigatiaffinis. FRONTIERS IN GENETICS, v. 11, MAY 12 2020. Web of Science Citations: 0.
ROCHA, MARINA CAMPOS; TADINI MARILHANO FABRI, JOAO HENRIQUE; SIMOES, ISABELLE TAIRA; SILVA-ROCHA, RAFAEL; HAGIWARA, DAISUKE; DA CUNHA, ANDERSON FERREIRA; GOLDMAN, GUSTAVO HENRIQUE; CANOVAS, DAVID; MALAVAZI, IRAN. The Cell Wall Integrity Pathway Contributes to the Early Stages of Aspergillus fumigatus Asexual Development. Applied and Environmental Microbiology, v. 86, n. 7 APR 2020. Web of Science Citations: 0.
BASTOS, RAFAEL WESLEY; VALERO, CLARA; SILVA, LILIAN PEREIRA; SCHOEN, TAYLOR; DROTT, MILTON; BRAUER, VERONICA; SILVA-ROCHA, RAFAEL; LIND, ABIGAIL; STEENWYK, JACOB L.; ROKAS, ANTONIS; RODRIGUES, FERNANDO; RESENDIZ-SHARPE, AGUSTIN; LAGROU, KATRIEN; MARCET-HOUBEN, MARINA; GABALDON, TONI; MCDONNELL, ERIN; REID, IAN; TSANG, ADRIAN; OAKLEY, BERL R.; LOURES, FLAVIO VIEIRA; ALMEIDA, FAUSTO; HUTTENLOCHER, ANNA; KELLER, NANCY P.; ANNICK RIES, LAURE NICOLAS; GOLDMAN, GUSTAVO H. Functional Characterization of Clinical Isolates of the Opportunistic Fungal Pathogen Aspergillus nidulans. MSPHERE, v. 5, n. 2 MAR-APR 2020. Web of Science Citations: 1.
DROTT, M. T.; BASTOS, R. W.; ROKAS, A.; RIES, L. N. A.; GABALDON, T.; GOLDMAN, G. H.; KELLER, N. P.; GRECO, C. Diversity of Secondary Metabolism in Aspergillus nidulans Clinical Isolates. MSPHERE, v. 5, n. 2 MAR-APR 2020. Web of Science Citations: 0.
ROKAS, ANTONIS; MEAD, MATTHEW E.; STEENWYK, JACOB L.; OBERLIES, NICHOLAS H.; GOLDMAN, GUSTAVO H. Evolving moldy murderers: Aspergillus section Fumigati as a model for studying the repeated evolution of fungal pathogenicity. PLOS PATHOGENS, v. 16, n. 2 FEB 2020. Web of Science Citations: 0.
KNOWLES, SONJA L.; MEAD, MATTHEW E.; SILVA, LILIAN PEREIRA; RAJA, HUZEFA A.; STEENWYK, JACOB L.; GOLDMAN, GUSTAVO H.; OBERLIES, NICHOLAS H.; ROKAS, ANTONIS. Gliotoxin, a Known Virulence Factor in the Major Human Pathogen Aspergillus fumigatus, Is Also Biosynthesized by Its Nonpathogenic Relative Aspergillus fischeri. MBIO, v. 11, n. 1 JAN-FEB 2020. Web of Science Citations: 0.
MATTOS, ELICIANE CEVOLANI; SILVA, LILIAN PEREIRA; VALERO, CLARA; DE CASTRO, PATRICIA ALVES; DOS REIS, THAILA FERNANDA; RIBEIRO, LILIANE F. C.; MARTEN, MARK R.; SILVA-ROCHA, RAFAEL; WESTMANN, CAUA; TOMICH DE PAULA DA SILVA, CARLOS HENRIQUE; TAFT, CARLTON ANTHONY; AL-FURAIJI, NARJES; BROMLEY, MICHAEL; MORTENSEN, UFFE H.; BENZ, J. PHILIPP; BROWN, NEIL ANDREW; GOLDMANA, GUSTAVO H. The Aspergillus fumigatus Phosphoproteome Reveals Roles of High-Osmolarity Glycerol Mitogen-Activated Protein Kinases in Promoting Cell Wall Damage and Caspofungin Tolerance. MBIO, v. 11, n. 1 JAN-FEB 2020. Web of Science Citations: 0.
FABRI, JOAO HENRIQUE T. M.; ROCHA, MARINA C.; MALAVAZI, IRAN. Overview of the Interplay Between Cell Wall Integrity Signaling Pathways and Membrane Lipid Biosynthesis in Fungi: Perspectives for Aspergillus fumigatus. CURRENT PROTEIN & PEPTIDE SCIENCE, v. 21, n. 3, p. 265-283, 2020. Web of Science Citations: 1.
BASTOS, RAFAEL WESLEY; ROSSATO, LUANA; VALERO, CLARA; LAGROU, KATRIEN; COLOMBO, ARNALDO LOPES; GOLDMAN, GUSTAVO H. Potential of Gallium as an Antifungal Agent. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 9, DEC 11 2019. Web of Science Citations: 0.
DE CASTRO, PATRICIA ALVES; COLABARDINI, ANA CRISTINA; MANFIOLLI, ADRIANA OLIVEIRA; CHIARATTO, JESSICA; SILVA, LILIAN PEREIRA; MATTOS, ELICIANE CEVOLANI; PALMISANO, GIUSEPPE; ALMEIDA, FAUSTO; PERSINOTI, GABRIELA FELIX; ANNICK RIES, LAURE NICOLAS; MELLADO, LAURA; ROCHA, MARINA CAMPOS; BROMLEY, MICHAEL; SILVA, ROBERTO NASCIMENTO; DE SOUZA, GABRIEL SCALINI; LOURES, FLAVIO VIEIRA; MALAVAZI, IRAN; BROWN, NEIL ANDREW; GOLDMAN, GUSTAVO H. Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistance. PLOS GENETICS, v. 15, n. 12 DEC 2019. Web of Science Citations: 0.
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MANFIOLLI, ADRIANA OLIVEIRA; SIQUEIRA, FILIPE SILVA; DOS REIS, THAILA FERNANDA; VAN DIJCK, PATRICK; SCHREVENS, SANNE; HOEFGEN, SANDRA; FOEGE, MARTIN; STRASSBURGER, MARIA; DE ASSIS, LEANDRO JOSE; HEINEKAMP, THORSTEN; ROCHA, MARINA CAMPOS; JANEVSKA, SLAVICA; BRAKHAGE, AXEL A.; MALAVAZI, IRAN; GOLDMAN, GUSTAVO H.; VALIANTE, VITO. Mitogen-Activated Protein Kinase Cross-Talk Interaction Modulates the Production of Melanins in Aspergillus fumigatus. MBIO, v. 10, n. 2 MAR-APR 2019. Web of Science Citations: 0.
ANNICK RIES, LAURE NICOLAS; DE ASSIS, LEANDRO JOSE; SANTOS RODRIGUES, FERNANDO JOSE; CALDANA, CAMILA; ROCHA, MARINA CAMPOS; MALAVAZI, IRAN; BAYRAM, OZGUR; GOLDMAN, GUSTAVO H. The Aspergillus nidulans Pyruvate Dehydrogenase Kinases Are Essential To Integrate Carbon Source Metabolism. G3-GENES, GENOMES, GENETICS, v. 8, n. 7, p. 2445-2463, JUL 2018. Web of Science Citations: 2.
DE ASSIS, LEANDRO JOSE; ULAS, MEVLUT; ANNICK RIES, LAURE NICOLAS; EL RAMLI, NADIA ALI MOHAMED; SARIKAYA-BAYRAM, OZLEM; BRAUS, GERHARD H.; BAYRAM, OZGUR; GOLDMAN, GUSTAVO HENRIQUE. Regulation of Aspergillus nidulans CreA-Mediated Catabolite Repression by the F-Box Proteins Fbx23 and Fbx47. MBIO, v. 9, n. 3 MAY-JUN 2018. Web of Science Citations: 4.
ANNICK RIES, LAURE NICOLAS; BEATTIE, SARAH; CRAMER, ROBERT A.; GOLDMAN, GUSTAVO H. Overview of carbon and nitrogen catabolite metabolism in the virulence of human pathogenic fungi. Molecular Microbiology, v. 107, n. 3, p. 277-297, FEB 2018. Web of Science Citations: 7.

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