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Characterizing the genomic and phenotypic diversity of clinical isolates from human fungal pathogens in the Aspergillus nidulans species complex

Grant number: 19/23231-4
Support type:Regular Research Grants
Duration: April 01, 2020 - March 31, 2022
Field of knowledge:Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
Cooperation agreement: Research Foundation - Flanders (FWO)
Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
Principal Investigator:Gustavo Henrique Goldman
Grantee:Gustavo Henrique Goldman
Principal investigator abroad: Katrien Lagrou
Institution abroad: University of Leuven (KU Leuven), Belgium
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Assoc. researchers: Agustin Resendiz Sharpe
Associated research grant:16/07870-9 - The influence of mitogen activated protein kinases (MAPK) on the expression of genetic determinants important for Aspergillus fumigatus virulence, AP.TEM

Abstract

Fungi are major contributors to human morbidity and mortality but we still know little about the molecular basis of their pathogenicity. Aspergillus-related diseases, collectively known as aspergillosis, are caused by various species in the Aspergillus genus of filamentous fungi. The saprophytic and ubiquitous airborne species Aspergillus fumigatus (section Fumigati) is responsible for most infections, however Aspergillus nidulans (section Nidulantes) is of interest because it is a major cause of invasive aspergillosis (IA) infections in chronic granulomatous disease (CGD) patients. CGD is a genetic disorder that occurs in 1 every 200,000 births and compromises the phagocytes ability to produce reactive oxygen species, which serve as a broad range chemical antimicrobial. Strikingly, among CGD patients, A. nidulans infections are characterized by their aggressive behavior and their difficulty to treat compared to A. fumigatus infections. The association of A. nidulans with a specific patient group population as CGD is highly unusual for human pathogenic Aspergillus species. However, the reasons for this are not fully understood as A. nidulans is poorly studied as a pathogen. (AU)