Advanced search
Start date

Molecular characterization of Aspergillus fumigatus transcription factors involved in calcium metabolism.

Grant number: 18/00715-3
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): May 01, 2018
Effective date (End): April 30, 2022
Field of knowledge:Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms
Principal Investigator:Gustavo Henrique Goldman
Grantee:Clara Isabel Valero Fernández
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:16/07870-9 - The influence of mitogen activated protein kinases (MAPK) on the expression of genetic determinants important for Aspergillus fumigatus virulence, AP.TEM
Associated scholarship(s):20/01131-5 - Identification of novel genes involved in stress response in Aspergillus fumigatus through quantitative barcode screening, BE.EP.PD


Invasive aspergillosis (IA) is one of the most important human fungal infections, especially for immunocompromised population, with Aspergillus fumigatus being the most detected fungal species. When the fungus invades human lungs, it has to adapt to host environment in order to survive and to develop virulence strategies. In that context, the capacity of fungal cell wall to adapt to external stresses plays and important role. The study of those pathways resulting in maintaining cell wall robustness will help in the discovery of future antifungal drug targets, since they seem to be essential in fungal viability. Recently, six transcription factors (TFs) with different degrees of calcium (Ca2+) sensitivity has been identified, four of which are completely novel, suggesting that they could be involved in the signaling pathway in response to Ca2+ affecting osmotic or other stress responses. Our main aim is to characterize the role played by three of these novel TFs in Ca2+ metabolism. This will be addressed by following these main objectives: i) to characterize Ca2+- dependent TFs, both genetically and phenotypically; ii) to identificate of Ca2+-dependent TFs targets through RNAseq and ChIPseq methodologies; iii) to investigate the connections of Ca2+-dependent TFs with other signaling pathways and iv) to analyze the role of Ca2+- dependent TFs in virulence by using animal infection models and to characterize immune response in cell culture.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
STEENWYK, JACOB L.; MEAD, MATTHEW E.; DE CASTRO, PATRICIA ALVES; VALERO, CLARA; DAMASIO, ANDRE; DOS SANTOS, RENATO A. C.; LABELLA, ABIGAIL L.; LI, YUANNING; KNOWLES, SONJA L.; RAJA, HUZEFA A.; et al. Genomic and Phenotypic Analysis of COVID-19-Associated Pulmonary Aspergillosis Isolates of Aspergillus fumigatus. MICROBIOLOGY SPECTRUM, v. 9, n. 1, . (19/07526-4, 17/21983-3, 18/00715-3)
DE CASTRO, PATRICIA ALVES; VALERO, CLARA; CHIARATTO, JESSICA; COLABARDINI, ANA CRISTINA; PARDESHI, LAKHANSING; SILVA, LILIAN PEREIRA; ALMEIDA, FAUSTO; ROCHA, MARINA CAMPOS; SILVA, ROBERTO NASCIMENTO; MALAVAZI, IRAN; et al. Novel Biological Functions of the NsdC Transcription Factor in Aspergillus fumigatus. MBIO, v. 12, n. 1, . (16/07870-9, 18/00715-3, 16/21392-2, 17/07536-4, 16/22062-6, 16/12948-7, 19/10097-8)
DA COSTA FILHO, AILTON PEREIRA; PEREIRA BRANCINI, GUILHERME THOMAZ; DE CASTRO, PATRICIA ALVES; VALERO, CLARA; FERREIRA FILHO, JAIRE ALVES; SILVA, LILIAN PEREIRA; ROCHA, MARINA CAMPOS; MALAVAZI, IRAN; DE MORAES PONTES, JOAO GUILHERME; FILL, TAICIA; et al. Aspergillus fumigatus G-Protein Coupled Receptors GprM and GprJ Are Important for the Regulation of the Cell Wall Integrity Pathway, Secondary Metabolite Production, and Virulence. MBIO, v. 11, n. 5, . (16/07870-9, 18/10962-8, 18/25217-6, 19/11929-7, 17/14159-2, 16/12948-7, 18/00715-3, 19/10727-1, 19/06359-7, 16/21392-2)
ANNICK RIES, LAURE NICOLAS; DE CASTRO, PATRICIA ALVES; SILVA, LILIAN PEREIRA; VALERO, CLARA; DOS REIS, THAILA FERNANDA; SABORANO, RAQUEL; DUARTE, IOLA F.; PERSINOTI, GABRIELA FELIX; STEENWYK, JACOB L.; ROKAS, ANTONIS; et al. spergillus fumigatus Acetate Utilization Impacts Virulence Traits and Pathogenicit. MBIO, v. 12, n. 4, . (16/07870-9, 17/14159-2, 17/08750-0, 16/12948-7, 18/00715-3)

Please report errors in scientific publications list by writing to: