Advanced search
Start date

The influence of mitogen activated protein kinases (MAPK) on the expression of genetic determinants important for Aspergillus fumigatus virulence

Grant number: 18/00315-5
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): February 01, 2018
Effective date (End): November 25, 2021
Field of knowledge:Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
Principal Investigator:Iran Malavazi
Grantee:Marina Campos Rocha
Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated research grant:16/07870-9 - The influence of mitogen activated protein kinases (MAPK) on the expression of genetic determinants important for Aspergillus fumigatus virulence, AP.TEM


MAP kinases and phosphatases are the main signaling pathways of tolerance to different kinds of stresses in eukaryotes. The multifactorial nature of A. fumigatus virulence and pathogenicity program in the mammalian host places the response to different kinds of stresses as one of the most important responses in the process of establishment of this organism as a pathogen. These signaling pathways are important for the cell wall biosynthesis and remodeling, responses to oxidative stress and antifungal drugs, biofilm formation and adhesion, and possibly other essential features not yet investigated such as, blood dissemination from the pulmonary epithelium and strategies of immunological evasion. The understanding of the metabolic nets that are coordinated by MAP kinases will provide an opportunity for the construction of the signaling pathways that are important for stress tolerance and the establishment of the A. fumigatus virulence and pathogenicity program in mammals. Thus, the main objectives of this project are: (i) the identification of specific transcription factors that are activated by different kinds of stress and that are dependent on MAP kinases; (ii) the identification of proteins that interact physically with the MAP kinases when A. fumigatus is exposed to different kinds of stresses; (iii) the investigation of a possible "crosstalk" among the different A. fumigatus MAP kinases during different kinds of stresses; (iv) the molecular characterization of MpkB and the verification if this MAP kinase is important for A. fumigatus virulence, and (v) the characterization of the interaction between the A. fumigatus mutants generated in this study and the immunosupressed and imunocompetent murine hosts.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BAZIOLI, JAQUELINE MORAES; FILL, TAICIA PACHECO; ROCHA, MARINA CAMPOS; MALAVAZI, IRAN; RODRIGUES FILHO, EDSON; DE MEDEIROS, LIVIA SOMAN. Perylenequinones production induced by co-culturing Setophoma sp. and Penicillium brasilianum. PHYTOCHEMISTRY LETTERS, v. 40, p. 76-83, . (19/04900-2, 18/00315-5, 19/06359-7, 19/11563-2, 09/18584-3)
AKIYAMA, DANIEL YURI; ROCHA, MARINA CAMPOS; COSTA, JONAS HENRIQUE; TELES, CAROLINE BRANDAO; ZUCCOLI, GIULIANA DA SILVA; MALAVAZI, IRAN; FILL, TAICIA PACHECO. The Penicillium brasilianum Histone Deacetylase Clr3 Regulates Secondary Metabolite Production and Tolerance to Oxidative Stress. JOURNAL OF FUNGI, v. 8, n. 5, p. 18-pg., . (19/06359-7, 18/13027-8, 17/19694-3, 18/14666-4, 18/00315-5, 17/25055-3, 16/07870-9)
VALERO, CLARA; COLABARDINI, ANA CRISTINA; DE CASTRO, PATRICIA ALVES; SILVA, LILIAN PEREIRA; RIES, LAURE NICOLAS ANNICK; PARDESHI, LAKHANSING; WANG, FANG; ROCHA, MARINA CAMPOS; MALAVAZI, IRAN; SILVA, ROBERTO NASCIMENTO; et al. Aspergillus Fumigatus ZnfA, a Novel Zinc Finger Transcription Factor Involved in Calcium Metabolism and Caspofungin Tolerance. FRONTIERS IN FUNGAL BIOLOGY, v. 2, p. 16-pg., . (16/21392-2, 17/07536-4, 16/12948-7, 16/07870-9, 18/00315-5, 17/19694-3, 18/00715-3, 17/14159-2)
PIVA, ROGER H.; ROCHA, MARINA C.; PIVA, DIOGENES H.; IMASATO, HIDETAKE; MALAVAZI, IRAN; RODRIGUES-FILHO, UBIRAJARA P.. Acidic Dressing Based on Agarose/Cs2.5H0.5PW12O40 Nanocomposite for Infection Control in Wound Care. ACS APPLIED MATERIALS & INTERFACES, v. 10, n. 37, p. 30963-30972, . (15/17541-0, 16/16098-8, 18/00315-5, 17/19694-3)
COLABARDINI, ANA CRISTINA; WANG, FANG; DONG, ZHIQIANG; PARDESHI, LAKHANSING; ROCHA, MARINA CAMPOS; COSTA, JONAS HENRIQUE; DOS REIS, THAILA FERNANDA; BROWN, ALEC; JABER, QAIS Z.; FRIDMAN, MICHA; et al. eterogeneity in the transcriptional response of the human pathogen Aspergillus fumigatus to the antifungal agent caspofungi. Genetics, v. 220, n. 1, . (18/00315-5, 17/07536-4, 17/19694-3, 16/07870-9)

Please report errors in scientific publications list using this form.