Autor(es)

Guerra Nista, Silvia Vaz ^[1] ; Bettini, Jefferson ^[2] ; Innocentini Mei, Lucia Helena ^[1]

Afiliação do(s) autor(es)

^[1] State Univ Campinas UNICAMP, Sch Chem Engn, Dept Mat Engn & Bioproc, Campinas, SP - Brazil

^[2] Brazilian Nanotechnol Natl Lab, Electron Microscopy Lab, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Carbohydrate Polymers; v. 127, p. 222-228, AUG 20 2015.
• Citações Web of Science: 34

Resumo

Electrospinning of mucoadhesive membranes is a new and promising field of investigation in the pharmaceutical and biomedical area. The present study explored the electrospinning of two mucoadhesive polymers, chitosan and alginate, to form a core-shell type nanofibers for future applications as controlled drug delivery. Due to the charged functional groups present in these natural polysaccharides, they can complex to,yield various nanodevices to be used in controlled release of several active ingredients. In this work, the core-shell type coaxial nanofibers formation was evidenced by the aid of transmission electron microscopy (TEM). Other characterization techniques as scanning electron microscopy (SEM), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Infrared spectroscopy (FTIR) and X-ray diffraction (XRD), strongly suggest the formation of different molecular structures of the membranes obtained by the complexation of chitosan and alginate. Swelling rate and weight loss tests followed by SEM analyses confirmed that the nanofiber structure of these membranes were kept even after incubating them for 24h in water. The results of this work confirmed that core-shell nanofibers made of chitosan and alginate polycomplex is possible to be obtained with success. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 13/04877-4 - Membranas de nanofibras com alta adesão para liberação bucal de fármacos
• Beneficiário: Lucia Helena Innocentini Mei
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/11904-5 - Membranas de nanofibras com alta adesão para liberação bucal de fármacos.
• Beneficiário: Silvia Vaz Guerra Nista
• Modalidade de apoio: Bolsas no Brasil - Doutorado