Polypropylene and polypropylene/polyglecaprone (Ultrapro (R)) meshes in the repair of incisional hernia in rats

Autor(es)

Utiyama, Edivaldo Massazo ^[1] ; Sartor de Faria Rosa, Maria Beatriz ^[2] ; Andres, Marina de Paula ^[2] ; de Miranda, Jocielle Santos ^[1] ; Bastos Damous, Sergio Henrique ^[1] ; Vianna Birolini, Claudio Augusto ^[1] ; Damous, Luciana Lamarao ^[3] ; de Souza Montero, Edna Frasson ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Dept Surg, Gen & Trauma Surg Div, BR-05508 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Sao Paulo Res Fdn FAPESP, Sci Initiat Grant, BR-05508 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Dept Obstet & Gynecol, BR-05508 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Sch Med, Dept Surg, Lab Surg Physiopathol LIM 62, BR-05508 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Acta Cirurgica Brasileira; v. 30, n. 6, p. 376-381, JUN 2015.
• Citações Web of Science: 5

Resumo

PURPOSE: To compare the inflammatory response of three different meshes on abdominal hernia repair in an experimental model of incisional hernia. METHODS: Median fascial incision and skin synthesis was performed on 30 Wistar rats. After 21 days, abdominal hernia developed was corrected as follows: 1) No mesh; 2) Polypropylene mesh; and, 3) Ultrapro (R) mesh. After 21 days, the mesh and surrounding tissue were submitted to macroscopic (presence of adhesions, mesh retraction), microscopic analysis to identify and quantify the inflammatory and fibrotic response using a score based on a predefined scale of 0-3 degrees, evaluating infiltration of macrophages, giant cells, neutrophils and lymphocytes. RESULTS: No significant difference was seen among groups in adherences, fibrosis, giant cells, macrophages, neutrophils or lymphocytes (p>0.05). Mesh shrinkage was observed in all groups, but also no difference was observed between polypropylene and Ultrapro mesh (7.0 +/- 9.9 vs. 7.4 +/- 10.1, respectively, p=0.967). Post-operatory complications included fistula, abscess, dehiscence, serohematic collection and reherniation, but with no difference among groups (p=0.363). CONCLUSION: There is no difference between polypropylene (high-density) and Ultrapro (R) (low-density) meshes at 21 days after surgery in extraperitoneal use in rats, comparing inflammatory response, mesh shortening, adhesions or complications. (AU)

• Processo FAPESP: 11/06111-3 - Estudo comparativo de três diferentes telas (polipropileno, poliglecaprone e poliglecaprone com filme) na reparação de hérnia incisional em ratos
• Beneficiário: Maria Beatriz Sartor de Faria
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica