Cortical correlates of affective syndrome in dementia due to Alzheimer's disease

Autor(es)

Hayata, Thais T. ^[1] ; Bergo, Felipe P. G. ^[1] ; Rezende, Thiago J. ^[1] ; Damasceno, Alfredo ^[1] ; Damasceno, Benito P. ^[1] ; Cendes, Fernando ^[1] ; Stella, Florindo ^{[2, 3]} ; Balthazar, Marcio L. F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Neurol, Lab Neuroimagem, Campinas, SP - Brazil

^[2] Univ Estadual Paulista, Inst Biociencias, Rio Claro, SP - Brazil

^[3] Univ Sao Paulo, Fac Med, Dept & Inst Psiquiatria, Lab Neurociencias, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Arquivos de Neuro-Psiquiatria; v. 73, n. 7, p. 553-560, JUL 2015.
• Citações Web of Science: 5

Resumo

Neuropsychiatric symptoms in Alzheimer's disease (AD) are prevalent, however their relationship with patterns of cortical atrophy is not fully known. Objectives: To compare cortical atrophy's patterns between AD patients and healthy controls; to verify correlations between neuropsychiatric syndromes and cortical atrophy. Method: 33 AD patients were examined by Neuropsychiatric Inventory (NPI). Patients and 29 controls underwent a 3T MRI scanning. We considered four NPI syndromes: affective, apathy, hyperactivity and psychosis. Correlations between structural imaging and neuropsychiatric scores were performed by Freesurfer. Results were significant with a p-value < 0.05, corrected for multiple comparisons. Results: Patients exhibited atrophy in entorhinal cortices, left inferior and middle temporal gyri, and precuneus bilaterally. There was correlation between affective syndrome and cortical thickness in right frontal structures, insula and temporal pole. Conclusion: Cortical thickness measures revealed atrophy in mild AD. Depression and anxiety symptoms were associated with atrophy of right frontal, temporal and insular cortices. (AU)

• Processo FAPESP: 11/17092-0 - Biomarcadores na Doença de Alzheimer e comprometimento cognitivo leve: estudo de métodos de ressonância magnética funcional e marcadores liquóricos e plasmáticos
• Beneficiário: Marcio Luiz Figueredo Balthazar
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 12/08291-1 - Correlação entre sintomas neuropsiquiátricos e espessura cortical em pacientes com Doença de Alzheimer
• Beneficiário: Thaís Tiemi Hayata
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica