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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cortical correlates of affective syndrome in dementia due to Alzheimer's disease

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Author(s):
Hayata, Thais T. [1] ; Bergo, Felipe P. G. [1] ; Rezende, Thiago J. [1] ; Damasceno, Alfredo [1] ; Damasceno, Benito P. [1] ; Cendes, Fernando [1] ; Stella, Florindo [2, 3] ; Balthazar, Marcio L. F. [1]
Total Authors: 8
Affiliation:
[1] Univ Estadual Campinas, Dept Neurol, Lab Neuroimagem, Campinas, SP - Brazil
[2] Univ Estadual Paulista, Inst Biociencias, Rio Claro, SP - Brazil
[3] Univ Sao Paulo, Fac Med, Dept & Inst Psiquiatria, Lab Neurociencias, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Arquivos de Neuro-Psiquiatria; v. 73, n. 7, p. 553-560, JUL 2015.
Web of Science Citations: 5
Abstract

Neuropsychiatric symptoms in Alzheimer's disease (AD) are prevalent, however their relationship with patterns of cortical atrophy is not fully known. Objectives: To compare cortical atrophy's patterns between AD patients and healthy controls; to verify correlations between neuropsychiatric syndromes and cortical atrophy. Method: 33 AD patients were examined by Neuropsychiatric Inventory (NPI). Patients and 29 controls underwent a 3T MRI scanning. We considered four NPI syndromes: affective, apathy, hyperactivity and psychosis. Correlations between structural imaging and neuropsychiatric scores were performed by Freesurfer. Results were significant with a p-value < 0.05, corrected for multiple comparisons. Results: Patients exhibited atrophy in entorhinal cortices, left inferior and middle temporal gyri, and precuneus bilaterally. There was correlation between affective syndrome and cortical thickness in right frontal structures, insula and temporal pole. Conclusion: Cortical thickness measures revealed atrophy in mild AD. Depression and anxiety symptoms were associated with atrophy of right frontal, temporal and insular cortices. (AU)

FAPESP's process: 11/17092-0 - Biomarkers in Alzheimer's Disease and mild cognitive impairment: evaluation of functional magnetic resonance imaging methods, plasmatic and cerebrospinal fluid markers
Grantee:Marcio Luiz Figueredo Balthazar
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 12/08291-1 - Correlation between neuropsychiatric symptoms and cortical thickness in patients with Alzheimer's Disease
Grantee:Thaís Tiemi Hayata
Support Opportunities: Scholarships in Brazil - Scientific Initiation