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Biomarkers in Alzheimer's Disease and mild cognitive impairment: evaluation of functional magnetic resonance imaging methods, plasmatic and cerebrospinal fluid markers

Grant number: 11/17092-0
Support Opportunities:Research Grants - Young Investigators Grants
Duration: April 01, 2013 - March 31, 2016
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Marcio Luiz Figueredo Balthazar
Grantee:Marcio Luiz Figueredo Balthazar
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated researchers:Benito Pereira Damasceno ; Carlos Otávio Brandão ; Felipe Paulo Guazzi Bergo ; Fernando Cendes ; Leonilda Maria Barbosa dos Santos
Associated grant(s):18/15571-7 - Mapping the progression of subjective cognitive decline to mild cognitive impairment and Alzheimer´s disease dementia with multimodal biomarkers, AP.JP2
Associated scholarship(s):14/25429-2 - Association between lobar microbleeds, CSF amyloid-beta, and epsilon-4 APOE allele in patients with dementia due to Alzheimer's Disease and mild cognitive impairment, BP.IC
14/02359-9 - Amnestic mild cognitive impairment with increased risk factor for Alzheimer's Disease: effect of cardiorespiratory training on clinical parameters and functional and structural neuroimaging, BP.DR
13/25857-1 - Relationship between different physiopathological processes in Alzheimer's Disease and Amnestic Mild Cognitive Impairment: the roles of inflammation, beta-amyloid, tau protein and APOE4 gene, BP.IC
13/10431-9 - Anatomical and functional connectivity in Default Mode and Salience Networks in mild dementia of Alzheimer's Disease and amnestic mild cognitive impairment, BP.DD
12/19128-4 - Biomarkers in Alzheimer's disease and Mild Cognitive Impairment: evaluation of functional magnetic resonance imaging methods, plasmatic and cerebrospinal fluid markers, BP.JP


Alzheimer's disease (AD) is among the most prevalent clinical conditions, mostly due to the population ageing. Also, among the most prevalent diseases, AD is the only which does not have effective prevention and treatment. One of the most relevant aspects in AD research is the development of biomarkers to characterize this disease in its earlier stage, aiming a better pharmacological management with current and future drugs. The new diagnostic criteria of AD (NIA-Alzheimer's Association 2011) include the use of biomarkers, which makes this study essential in our country. In this project, our main objectives are: 1) To start a new line in our Institution of translational research in AD, which promotes research into various aspects of the disease. Specifically, the study of pathophysiological mechanisms such as determination of beta-amyloid protein and total tau and phosphorylated tau in cerebrospinal fluid (CSF) and inflammatory markers like interleucine (IL) 1, IL-6, IL-10, IL-12, IL-18, Tumoral Necrosis Factor-alpha, alpha1-antichymotrypsin and TGF² in plasma and CSF. 2) To create ideal conditions for our center to take part actively in the Brazilian version of Alzheimer's Disease Neuroimaging Initiative (ADNI - Brazil), under discussion by the Brazilian Academy of Neurology. Specifically, we will study techniques for functional and structural neuroimaging. The functional MRI is a method with high potential to become an image biomarker, by using the method without cognitive tasks (intrinsic functional connectivity), which can identify the integrity of certain neurofunctional networks. We aim to correlate this method with structural neuroimaging (volumetry, voxel-based morphometry, tractography, cortical thickness). All these data will be evaluated in conjunction with cognitive, neuropsychiatric and functional aspects. This project features a new line of research in our Institution and may contribute significantly to the creation of a national network of neuroimaging in dementia, like ADNI, which exists in the U.S., Europe and Japan. (AU)

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOURENCO, RAFAEL BRANDES; DE CAMPOS, BRUNNO MACHADO; RIZZI, LIARA; DE SOUZA, MILENE SAKZENIAN; FORLENZA, ORESTES VICENTE; JOAQUIM, HELENA GIROUD; TALIB, LEDA LEME; CENDES, FERNANDO; FIGUEREDO BALTHAZAR, MARCIO LUIZ. Functional Connectome Analysis in Mild Cognitive Impairment: Comparing Alzheimer's Disease Continuum and Suspected Non-Alzheimer Pathology. BRAIN CONNECTIVITY, v. 12, n. 9, p. 10-pg., . (17/13906-9, 11/17092-0, 18/15571-7)
WEILER, MARINA; CENDES, FERNANDO; BALTHAZAR, MARCIO L. F.. Comparing regional brain atrophy in mild cognitive impairment and Alzheimer's disease. NEURODEGENERATIVE DISEASE MANAGEMENT, v. 3, n. 5, p. 10-pg., . (11/17092-0)
THAÍS T. HAYATA; FELIPE P. G. BERGO; THIAGO J. REZENDE; ALFREDO DAMASCENO; BENITO P. DAMASCENO; FERNANDO CENDES; FLORINDO STELLA; MARCIO L. F. BALTHAZAR. Correlatos corticais da síndrome afetiva na demência da doença de Alzheimer. Arquivos de Neuro-Psiquiatria, v. 73, n. 7, p. 553-560, . (12/08291-1, 11/17092-0)
HAYATA, THAIS T.; BERGO, FELIPE P. G.; REZENDE, THIAGO J.; DAMASCENO, ALFREDO; DAMASCENO, BENITO P.; CENDES, FERNANDO; STELLA, FLORINDO; BALTHAZAR, MARCIO L. F.. Cortical correlates of affective syndrome in dementia due to Alzheimer's disease. Arquivos de Neuro-Psiquiatria, v. 73, n. 7, p. 553-560, . (11/17092-0, 12/08291-1)
WEILER, MARINA; LIGO TEIXEIRA, CAMILA VIEIRA; NOGUEIRA, MATEUS HENRIQUE; DE CAMPOS, BRUNNO MACHADO; DAMASCENO, BENITO PEREIRA; CENDES, FERNANDO; FIGUEREDO BALTHAZAR, MARCIO LUIZ. Differences and the Relationship in Default Mode Network Intrinsic Activity and Functional Connectivity in Mild Alzheimer's Disease and Amnestic Mild Cognitive Impairment. BRAIN CONNECTIVITY, v. 4, n. 8, p. 8-pg., . (11/17092-0, 13/10431-9)
WEILER, MARINA; DE CAMPOS, BRUNNO MACHADO; NOGUEIRA, MATEUS HENRIQUE; DAMASCENO, BENITO PEREIRA; CENDES, FERNANDO; BALTHAZAR, MARCIO L. F.. Structural connectivity of the default mode network and cognition in Alzheimer's disease. PSYCHIATRY RESEARCH-NEUROIMAGING, v. 223, n. 1, p. 15-22, . (11/17092-0, 13/10431-9)
FIGUEREDO BALTHAZAR, MARCIO LUIZ; DE CAMPOS, BRUNNO MACHADO; FRANCO, ALEXANDRE ROSA; DAMASCENO, BENITO PEREIRA; CENDES, FERNANDO. Whole cortical and default mode network mean functional connectivity as potential biomarkers for mild Alzheimer's disease. PSYCHIATRY RESEARCH-NEUROIMAGING, v. 221, n. 1, p. 37-42, . (11/17092-0)
WEILER, MARINA; FUKUDA, AYA; MASSABKI, LILIAN H. P.; LOPES, TATILA M.; FRANCO, ALEXANDRE R.; DAMASCENO, BENITO P.; CENDES, FERNANDO; BALTHAZAR, MARCIO L. F.. Default Mode, Executive Function, and Language Functional Connectivity Networks are Compromised in Mild Alzheimer's Disease. Current Alzheimer Research, v. 11, n. 3, p. 274-282, . (11/17092-0, 13/10431-9)

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