Correlations between cognitive performance and cortical gray matter in patients with subjective cognitive decline and mild cognitive impairment according to AT(N) classification

• Grant number: 20/02140-8
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): March 01, 2020
• Effective date (End): April 30, 2022
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Marcio Luiz Figueredo Balthazar
• Grantee: Brenda Costa Gonçalves
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 18/15571-7 - Mapping the progression of subjective cognitive decline to mild cognitive impairment and Alzheimer´s disease dementia with multimodal biomarkers, AP.JP2

Abstract

Mild Cognitive Impairment (CCL) and Subjective Cognitive Decline (DCS) are considered possible preclinical indicators of Alzheimer's Disease (AD). Thus, the risks of increased conversion rate (10 to 15% per year) for prevalence are higher in patients with these conditions. Given this, increase the need for studies that previously alter consultations, to aid in early diagnosis and thus increase the chances of applying more assertive and perform. This study aims to evaluate the neuropsychological and structural neuroimaging profile (gray matter) of patients with DCS and CCL, subdivided according to the AT (N) classification, which covers three main biomarkers of AD (²A peptide, tau protein, and neurodegeneration). The categorization of individuals will be used in the following profiles: pathophysiology DA, SNAP and normal compared to economic controls. For this, participants classified as DCS and CCL will undergo neuropsychological evaluation, magnetic resonance imaging (MRI), blood and cerebrospinal fluid (CSF) collection. Controls, according to the Ethics Committee, will collect the liquid only if desired, using the Consent Form. (AU)