Anatomical and functional connectivity in Default Mode and Salience Networks in mild dementia of Alzheimer's Disease and amnestic mild cognitive impairment

• Grant number: 13/10431-9
• Support type: Scholarships in Brazil - Doctorate (Direct)
• Effective date (Start): September 01, 2013
• Effective date (End): July 31, 2015
• Field of knowledge: Health Sciences - Medicine
• Principal researcher: Marcio Luiz Figueredo Balthazar
• Grantee: Marina Weiler
• Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 11/17092-0 - Biomarkers in Alzheimer's Disease and mild cognitive impairment: evaluation of functional magnetic resonance imaging methods, plasmatic and cerebrospinal fluid markers, AP.JP
• Associated scholarship(s): 14/00144-5 - Functional connectivity of default mode network in Alzheimer's disease and mild cognitive impairment, BE.EP.DD

Abstract

Alzheimer's Disease (AD) is the leading cause of dementia in the aging population. Recent research in neuroimaging has revealed dysfunction not only in anatomical areas but also in neural networks in AD patients. The most commonly studied network in AD is the Default Mode Network (DMN), which is related to episodic memory processing and cognitive performance. On the other hand, the Salience Network (SN), which is part of the 'attention system' and related to emotional stimuli, has been studied less frequently. Using functional Magnetic Resonance Imaging (fMRI) and Diffusion Tensor Imaging (DTI) it is possible to generate an anatomical map and in vivo neural network brain map which, when combined, offer a novel approach for studying neural networks in AD. The main objective of this project is to combine fMRI and DTI methods to further analyze the DMN and particularly the SN networks in AD. To my knowledge, this is the first study to investigate AD progression using both methods. Such a study would improve our knowledge of structural alterations in neuronal networks throughout the progression of AD. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

WEILER, MARINA; DE CAMPOS, BRUNNO MACHADO; DE LIGO TEIXEIRA, CAMILA VIEIRA; CASSEB, RAPHAEL FERNANDES; MAC KNIGHT CARLETTI-CASSANI, ANA FLAVIA; VICENTINI, JESSICA ELIAS; CARDOSO MAGALHAES, THAMIRES NAELA; TALIB, LEDA LEME; FORLENZA, ORESTES VICENTE; FIGUEREDO BALTHAZAR, MARCIO LUIZ. Intranetwork and internetwork connectivity in patients with Alzheimer disease and the association with cerebrospinal fluid biomarker levels. JOURNAL OF PSYCHIATRY & NEUROSCIENCE, v. 42, n. 6, p. 366-377, NOV 2017. Web of Science Citations: 3.

WEILER, MARINA; NORTHOFF, GEORG; DAMASCENO, BENITO PEREIRA; FIGUEREDO BALTHAZAR, MARCIO LUIZ. Self, cortical midline structures and the resting state: Implications for Alzheimer's disease. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 68, p. 245-255, SEP 2016. Web of Science Citations: 8.

WEILER, MARINA; DE CAMPOS, BRUNNO MACHADO; NOGUEIRA, MATEUS HENRIQUE; DAMASCENO, BENITO PEREIRA; CENDES, FERNANDO; BALTHAZAR, MARCIO L. F. Structural connectivity of the default mode network and cognition in Alzheimer's disease. PSYCHIATRY RESEARCH-NEUROIMAGING, v. 223, n. 1, p. 15-22, JUL 30 2014. Web of Science Citations: 13.

WEILER, MARINA; FUKUDA, AYA; MASSABKI, LILIAN H. P.; LOPES, TATILA M.; FRANCO, ALEXANDRE R.; DAMASCENO, BENITO P.; CENDES, FERNANDO; BALTHAZAR, MARCIO L. F. Default Mode, Executive Function, and Language Functional Connectivity Networks are Compromised in Mild Alzheimer's Disease. Current Alzheimer Research, v. 11, n. 3, p. 274-282, MAR 2014. Web of Science Citations: 18.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

WEILER, Marina. Evaluation by magnetic resonance imaging of functional and structural connectivities of neurofunctional networks in mild Alzheimer's disease dementia and amnestic mild cognitive impairment subjects. 2015. Doctoral Thesis - Universidade Estadual de Campinas. Faculdade de Ciências Médicas.