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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Self, cortical midline structures and the resting state: Implications for Alzheimer's disease

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Author(s):
Weiler, Marina ; Northoff, Georg ; Damasceno, Benito Pereira ; Figueredo Balthazar, Marcio Luiz
Total Authors: 4
Document type: Review article
Source: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS; v. 68, p. 245-255, SEP 2016.
Web of Science Citations: 8
Abstract

Different aspects of the self have been reported to be affected in many neurological or psychiatric diseases such as Alzheimer's disease (AD), including mainly higher-level cognitive self-unawareness. This higher sense of self-awareness is most likely related to and dependent on episodic memory, due to the proper integration of ourselves in time, with a permanent conservation of ourselves (i.e., sense of continuity across time). Reviewing studies in this field, our objective is thus to raise possible explanations, especially with the help of neuroimaging studies, for where such self-awareness deficits originate in AD patients. We describe not only episodic (and autobiographical memory) impairment in patients, but also the important role of cortical midline structures, the Default Mode Network, and the resting state (intrinsic brain activity) for the processing of self-related information. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 13/10431-9 - Anatomical and functional connectivity in Default Mode and Salience Networks in mild dementia of Alzheimer's Disease and amnestic mild cognitive impairment
Grantee:Marina Weiler
Support type: Scholarships in Brazil - Doctorate (Direct)