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Amnestic mild cognitive impairment with increased risk factor for Alzheimer's Disease: effect of cardiorespiratory training on clinical parameters and functional and structural neuroimaging

Grant number: 14/02359-9
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2014
Effective date (End): February 03, 2018
Field of knowledge:Health Sciences - Medicine
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Marcio Luiz Figueredo Balthazar
Grantee:Camila Vieira Ligo Teixeira
Host Institution: Hospital de Clínicas (HC). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:11/17092-0 - Biomarkers in Alzheimer's Disease and mild cognitive impairment: evaluation of functional magnetic resonance imaging methods, plasmatic and cerebrospinal fluid markers, AP.JP
Associated scholarship(s):15/19244-2 - Amnestic mild cognitive impairment with increased risk factor for Alzheimer's Disease: effect of cardiorespiratory training on cerebral blood flow, BE.EP.DR


Alzheimer's disease (AD) is a degenerative disorder that causes cognitive impairment and dependence in activities of daily life. It is the main cause of dementia in the elderly population. Biomarkers that reflect the pathophysiology of AD, such as the presence of hippocampal atrophy or molecular markers in cerebrospinal fluid (CSF) increase the reliability of clinical diagnosis. The term Mild Cognitive Impairment (MCI) is used to diagnose patients with clinical decline in one or more cognitive domains, but with normal social and functional performance. These patients have a greater chance of developing AD, and the presence of these biomarkers increases that chance. Aerobic exercises seem to be effective in improving cognition and socio-functional activities in elderly, but so far no studies proving the efficacy of aerobic exercise in MCI with increased risk for AD have been made. Thus the aim of this study is to assess the effect of 12 months of supervised or non-supervised aerobic exercise in episodic memory, daily life activities and structure, cerebral perfusion and connectivity of older people with amnestic MCI with biological evidence of increased risk for dementia in AD, hoping to obtain data to input assumptions about the actual effect of aerobic exercises with increased risk in this group. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TEIXEIRA, CAMILA V. L.; WEILER, MARINA; VICENTINI, JESSICA E.; JUNQUEIRA, THIAGO; CENDES, FERNANDO; BALTHAZAR, MARCIO L. F.. Physical Activity and Hippocampus Volume in Alzheimer Disease, Mild Cognitive Impairment and Normal Cognitive Elderly. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 47, n. 5, p. 2-pg., . (14/02359-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
TEIXEIRA, Camila Vieira Ligo. Multifunctional training on subjects with amnestic mild cognitive impairment due to AD: effects on clinical parameters and functional and structural neuroimaging. 2018. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.

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